Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057911780> ?p ?o ?g. }
- W2057911780 endingPage "10" @default.
- W2057911780 startingPage "1" @default.
- W2057911780 abstract "Objective . It has been suggested that atypical antipsychotics confer their effects via brain-derived neurotrophic factor (BDNF). We investigated the effect of quetiapine on serum levels of BDNF and vascular endothelial growth factor (VEGF) in drug-naive first-episode psychosis subjects. Methods . Fifteen patients drawn from a larger study received quetiapine treatment for twelve weeks. Baseline levels of serum BDNF and VEGF were compared to age- and sex-matched healthy controls and to levels following treatment. Linear regression analyses were performed to determine the relationship of BDNF and VEGF levels with outcome measures at baseline and week 12. Results . The mean serum BDNF level was significantly higher at week 12 compared to baseline and correlated with reductions in Brief Psychiatric Rating Scale (BPRS) and general psychopathology scores. Changes in serum VEGF levels also correlated significantly with a reduction in BPRS scores, a significant improvement in PANNS positive symptoms scores, and displayed a positive relationship with changes in BDNF levels. Conclusions . Our findings suggest that BDNF and VEGF are potential biomarkers for gauging improvement of psychotic symptoms. This suggests a novel neurotrophic-based mechanism of the drug effects of quetiapine on psychosis. This is the first report of VEGF perturbation in psychosis." @default.
- W2057911780 created "2016-06-24" @default.
- W2057911780 creator A5001786241 @default.
- W2057911780 creator A5016731198 @default.
- W2057911780 creator A5033459023 @default.
- W2057911780 creator A5043110852 @default.
- W2057911780 creator A5043282945 @default.
- W2057911780 creator A5052976583 @default.
- W2057911780 creator A5066622660 @default.
- W2057911780 creator A5066753080 @default.
- W2057911780 creator A5073636761 @default.
- W2057911780 creator A5084020146 @default.
- W2057911780 date "2014-01-01" @default.
- W2057911780 modified "2023-09-25" @default.
- W2057911780 title "Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis" @default.
- W2057911780 cites W117431324 @default.
- W2057911780 cites W1496088120 @default.
- W2057911780 cites W1642086117 @default.
- W2057911780 cites W1656703530 @default.
- W2057911780 cites W1971640746 @default.
- W2057911780 cites W1972280500 @default.
- W2057911780 cites W1973271647 @default.
- W2057911780 cites W1975174830 @default.
- W2057911780 cites W1977043096 @default.
- W2057911780 cites W1979636870 @default.
- W2057911780 cites W1979794821 @default.
- W2057911780 cites W1980915402 @default.
- W2057911780 cites W1981870344 @default.
- W2057911780 cites W1981982288 @default.
- W2057911780 cites W1982669529 @default.
- W2057911780 cites W1987400033 @default.
- W2057911780 cites W1988210171 @default.
- W2057911780 cites W1991049734 @default.
- W2057911780 cites W1993663522 @default.
- W2057911780 cites W1993709046 @default.
- W2057911780 cites W1993852924 @default.
- W2057911780 cites W1994965473 @default.
- W2057911780 cites W1995230642 @default.
- W2057911780 cites W1999128166 @default.
- W2057911780 cites W2000278115 @default.
- W2057911780 cites W2000845566 @default.
- W2057911780 cites W2002844435 @default.
- W2057911780 cites W2004107819 @default.
- W2057911780 cites W2007719377 @default.
- W2057911780 cites W2008853092 @default.
- W2057911780 cites W2010269783 @default.
- W2057911780 cites W2011961744 @default.
- W2057911780 cites W2013373204 @default.
- W2057911780 cites W2014204077 @default.
- W2057911780 cites W2016354522 @default.
- W2057911780 cites W2019885827 @default.
- W2057911780 cites W2023323938 @default.
- W2057911780 cites W2025027835 @default.
- W2057911780 cites W2025246597 @default.
- W2057911780 cites W2025292926 @default.
- W2057911780 cites W2028304295 @default.
- W2057911780 cites W2029314358 @default.
- W2057911780 cites W2032487256 @default.
- W2057911780 cites W2032804593 @default.
- W2057911780 cites W2035172439 @default.
- W2057911780 cites W2035906586 @default.
- W2057911780 cites W2036432978 @default.
- W2057911780 cites W2037458311 @default.
- W2057911780 cites W2039636801 @default.
- W2057911780 cites W2040973360 @default.
- W2057911780 cites W2041234594 @default.
- W2057911780 cites W2041609945 @default.
- W2057911780 cites W2047296228 @default.
- W2057911780 cites W2047672109 @default.
- W2057911780 cites W2050062456 @default.
- W2057911780 cites W2050601953 @default.
- W2057911780 cites W2054985002 @default.
- W2057911780 cites W2062207971 @default.
- W2057911780 cites W2062361204 @default.
- W2057911780 cites W2063839886 @default.
- W2057911780 cites W2064406129 @default.
- W2057911780 cites W2071026107 @default.
- W2057911780 cites W2071532773 @default.
- W2057911780 cites W2075212947 @default.
- W2057911780 cites W2080407061 @default.
- W2057911780 cites W2082620135 @default.
- W2057911780 cites W2084661664 @default.
- W2057911780 cites W2085292494 @default.
- W2057911780 cites W2086836130 @default.
- W2057911780 cites W2106491646 @default.
- W2057911780 cites W2112894153 @default.
- W2057911780 cites W2116914859 @default.
- W2057911780 cites W2116947209 @default.
- W2057911780 cites W2119867997 @default.
- W2057911780 cites W2121640875 @default.
- W2057911780 cites W2122606472 @default.
- W2057911780 cites W2124366353 @default.
- W2057911780 cites W2126265100 @default.
- W2057911780 cites W2134678910 @default.
- W2057911780 cites W2136614794 @default.
- W2057911780 cites W2139383568 @default.
- W2057911780 cites W2153669504 @default.
- W2057911780 cites W2155682492 @default.