FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057914919> ?p ?o ?g. }

• W2057914919 endingPage "597" @default.
• W2057914919 startingPage "589" @default.
• W2057914919 abstract "Mammalian mitochondrial initiation factor 3 (IF3(mt)) has a central region with homology to bacterial IF3. This homology region is preceded by an N-terminal extension and followed by a C-terminal extension. The role of these extensions on the binding of IF3(mt) to mitochondrial small ribosomal subunits (28S) was studied using derivatives in which the extensions had been deleted. The K(d) for the binding of IF3(mt) to 28S subunits is approximately 30 nM. Removal of either the N- or C-terminal extension has almost no effect on this value. IF3(mt) has very weak interactions with the large subunit of the mitochondrial ribosome (39S) (K(d) = 1.5 muM). However, deletion of the extensions results in derivatives with significant affinity for 39S subunits (K(d) = 0.12-0.25 muM). IF3(mt) does not bind 55S monosomes, while the deletion derivative binds slightly to these particles. IF3(mt) is very effective in dissociating 55S ribosomes. Removal of the N-terminal extension has little effect on this activity. However, removal of the C-terminal extension leads to a complex dissociation pattern due to the high affinity of this derivative for 39S subunits. These data suggest that the extensions have evolved to ensure the proper dissociation of IF3(mt) from the 28S subunits upon 39S subunit joining." @default.
• W2057914919 created "2016-06-24" @default.
• W2057914919 creator A5024379963 @default.
• W2057914919 creator A5056487298 @default.
• W2057914919 creator A5081565789 @default.
• W2057914919 date "2007-12-01" @default.
• W2057914919 modified "2023-09-26" @default.
• W2057914919 title "The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3 mt" @default.
• W2057914919 cites W1489829446 @default.
• W2057914919 cites W1503787361 @default.
• W2057914919 cites W1554525826 @default.
• W2057914919 cites W1565711624 @default.
• W2057914919 cites W1566509230 @default.
• W2057914919 cites W1585024604 @default.
• W2057914919 cites W1648194376 @default.
• W2057914919 cites W1918388863 @default.
• W2057914919 cites W1966074306 @default.
• W2057914919 cites W1969111603 @default.
• W2057914919 cites W1971976535 @default.
• W2057914919 cites W1976199676 @default.
• W2057914919 cites W1976339737 @default.
• W2057914919 cites W1984463295 @default.
• W2057914919 cites W1986908018 @default.
• W2057914919 cites W1990636869 @default.
• W2057914919 cites W2013916265 @default.
• W2057914919 cites W2015440391 @default.
• W2057914919 cites W2024343736 @default.
• W2057914919 cites W2028449522 @default.
• W2057914919 cites W2032826258 @default.
• W2057914919 cites W2033414595 @default.
• W2057914919 cites W2037213262 @default.
• W2057914919 cites W2037679031 @default.
• W2057914919 cites W2041941489 @default.
• W2057914919 cites W2044710235 @default.
• W2057914919 cites W2046055395 @default.
• W2057914919 cites W2056365366 @default.
• W2057914919 cites W2057160549 @default.
• W2057914919 cites W2074639004 @default.
• W2057914919 cites W2078105773 @default.
• W2057914919 cites W2080294804 @default.
• W2057914919 cites W2084879105 @default.
• W2057914919 cites W2084904678 @default.
• W2057914919 cites W2087167298 @default.
• W2057914919 cites W2092173144 @default.
• W2057914919 cites W2120498503 @default.
• W2057914919 cites W2124433456 @default.
• W2057914919 cites W2134233533 @default.
• W2057914919 cites W2144970210 @default.
• W2057914919 cites W2148014433 @default.
• W2057914919 cites W2149357806 @default.
• W2057914919 cites W2149454948 @default.
• W2057914919 cites W2171108120 @default.
• W2057914919 cites W2923667469 @default.
• W2057914919 cites W768968990 @default.
• W2057914919 doi "https://doi.org/10.1093/nar/gkm1072" @default.
• W2057914919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2241858" @default.
• W2057914919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18056078" @default.
• W2057914919 hasPublicationYear "2007" @default.
• W2057914919 type Work @default.
• W2057914919 sameAs 2057914919 @default.
• W2057914919 citedByCount "32" @default.
• W2057914919 countsByYear W20579149192012 @default.
• W2057914919 countsByYear W20579149192013 @default.
• W2057914919 countsByYear W20579149192015 @default.
• W2057914919 countsByYear W20579149192016 @default.
• W2057914919 countsByYear W20579149192018 @default.
• W2057914919 countsByYear W20579149192019 @default.
• W2057914919 countsByYear W20579149192020 @default.
• W2057914919 countsByYear W20579149192023 @default.
• W2057914919 crossrefType "journal-article" @default.
• W2057914919 hasAuthorship W2057914919A5024379963 @default.
• W2057914919 hasAuthorship W2057914919A5056487298 @default.
• W2057914919 hasAuthorship W2057914919A5081565789 @default.
• W2057914919 hasBestOaLocation W20579149191 @default.
• W2057914919 hasConcept C104292427 @default.
• W2057914919 hasConcept C104317684 @default.
• W2057914919 hasConcept C105580179 @default.
• W2057914919 hasConcept C129194359 @default.
• W2057914919 hasConcept C149364088 @default.
• W2057914919 hasConcept C153911025 @default.
• W2057914919 hasConcept C4718897 @default.
• W2057914919 hasConcept C55493867 @default.
• W2057914919 hasConcept C62493599 @default.
• W2057914919 hasConcept C67705224 @default.
• W2057914919 hasConcept C86803240 @default.
• W2057914919 hasConcept C88478588 @default.
• W2057914919 hasConcept C95444343 @default.
• W2057914919 hasConcept C97154109 @default.
• W2057914919 hasConceptScore W2057914919C104292427 @default.
• W2057914919 hasConceptScore W2057914919C104317684 @default.
• W2057914919 hasConceptScore W2057914919C105580179 @default.
• W2057914919 hasConceptScore W2057914919C129194359 @default.
• W2057914919 hasConceptScore W2057914919C149364088 @default.
• W2057914919 hasConceptScore W2057914919C153911025 @default.
• W2057914919 hasConceptScore W2057914919C4718897 @default.
• W2057914919 hasConceptScore W2057914919C55493867 @default.
• W2057914919 hasConceptScore W2057914919C62493599 @default.
• W2057914919 hasConceptScore W2057914919C67705224 @default.

• next