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- W2057915804 abstract "It has been reported that rats develop tolerance to the milk intake suppressant effects of d-amphetamine, d-amphetamine, and d, l-fenfluramine. However, it has been hypothesized that the mechanism of action of fenfluramine is different from that of the other two drugs. In the present experiment, rats were given one of these 3 phenylethylamine derivatives each day until tolerance developed to the suppression of milk intake. A second of these drugs was then substituted and milk intake measured. There was cross-tolerance to the drug-induced suppression between d-amphetamine and d-methamphetamine, but not between d-amphetamine and d,l-fenfluramine. The lack of cross tolerance suggests a different mechanism of action for these drugs." @default.
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- W2057915804 date "1975-07-01" @default.
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- W2057915804 title "Tolerance and cross-tolerance to the effects of amphetamine, methamphetamine and fenfluramine on milk consumption in the rat" @default.
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- W2057915804 doi "https://doi.org/10.1016/0091-3057(75)90197-5" @default.
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