Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057925304> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2057925304 endingPage "1177" @default.
- W2057925304 startingPage "1173" @default.
- W2057925304 abstract "The temperature dependence of the kinetics of efflux of melphalan from Chinese hamster ovary (CHO) cells was studied from 4 degrees to 47 degrees. Time courses for melphalan efflux showed an initial rapid phase of efflux followed by a plateau. The data for melphalan concentration (c) versus efflux time (t) were described by the equation c(t) = A + B exp(-kt), where A is the final steady-state melphalan concentration, B is the total change in melphalan concentration from time zero until steady-state conditions are reached, and k is the rate constant for the efflux process. The plateau level obtained was not dependent on temperature and corresponded to 22 +/- 3.2% of the drug remaining in the cells after efflux. The time for melphalan efflux to reach the plateau level was dependent on temperature. This was reflected by an increase in the rate constants for melphalan efflux with increasing temperature from 30 degrees to 47 degrees. The rate constant for melphalan efflux at 37 degrees was 0.045 +/- 0.002 min-1. Efflux of melphalan occurred much more slowly at lower temperatures such as 4 degrees and 20 degrees. An Arrhenius plot for melphalan efflux showed a linear and decreasing trend at temperatures between 30 degrees and 47 degrees with an activation energy of 1.046 x 10(3) J/mol." @default.
- W2057925304 created "2016-06-24" @default.
- W2057925304 creator A5014570718 @default.
- W2057925304 creator A5075264135 @default.
- W2057925304 date "1991-04-01" @default.
- W2057925304 modified "2023-10-16" @default.
- W2057925304 title "Temperature dependence of melphalan efflux kinetics in Chinese hamster ovary cells" @default.
- W2057925304 cites W1986369051 @default.
- W2057925304 cites W2034031399 @default.
- W2057925304 cites W2038075864 @default.
- W2057925304 cites W2040663766 @default.
- W2057925304 cites W2044729382 @default.
- W2057925304 cites W2069415301 @default.
- W2057925304 cites W2072885226 @default.
- W2057925304 cites W2124242608 @default.
- W2057925304 cites W2153630881 @default.
- W2057925304 cites W2418139010 @default.
- W2057925304 cites W1556006348 @default.
- W2057925304 doi "https://doi.org/10.1016/0006-2952(91)90655-o" @default.
- W2057925304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2009093" @default.
- W2057925304 hasPublicationYear "1991" @default.
- W2057925304 type Work @default.
- W2057925304 sameAs 2057925304 @default.
- W2057925304 citedByCount "6" @default.
- W2057925304 countsByYear W20579253042020 @default.
- W2057925304 crossrefType "journal-article" @default.
- W2057925304 hasAuthorship W2057925304A5014570718 @default.
- W2057925304 hasAuthorship W2057925304A5075264135 @default.
- W2057925304 hasConcept C112705442 @default.
- W2057925304 hasConcept C121332964 @default.
- W2057925304 hasConcept C134018914 @default.
- W2057925304 hasConcept C134306372 @default.
- W2057925304 hasConcept C147789679 @default.
- W2057925304 hasConcept C148898269 @default.
- W2057925304 hasConcept C170493617 @default.
- W2057925304 hasConcept C175656101 @default.
- W2057925304 hasConcept C185592680 @default.
- W2057925304 hasConcept C200082930 @default.
- W2057925304 hasConcept C2776694085 @default.
- W2057925304 hasConcept C2778575167 @default.
- W2057925304 hasConcept C2778684742 @default.
- W2057925304 hasConcept C2780030769 @default.
- W2057925304 hasConcept C33923547 @default.
- W2057925304 hasConcept C3941253 @default.
- W2057925304 hasConcept C54355233 @default.
- W2057925304 hasConcept C55493867 @default.
- W2057925304 hasConcept C62520636 @default.
- W2057925304 hasConcept C8171440 @default.
- W2057925304 hasConcept C86803240 @default.
- W2057925304 hasConcept C98274493 @default.
- W2057925304 hasConceptScore W2057925304C112705442 @default.
- W2057925304 hasConceptScore W2057925304C121332964 @default.
- W2057925304 hasConceptScore W2057925304C134018914 @default.
- W2057925304 hasConceptScore W2057925304C134306372 @default.
- W2057925304 hasConceptScore W2057925304C147789679 @default.
- W2057925304 hasConceptScore W2057925304C148898269 @default.
- W2057925304 hasConceptScore W2057925304C170493617 @default.
- W2057925304 hasConceptScore W2057925304C175656101 @default.
- W2057925304 hasConceptScore W2057925304C185592680 @default.
- W2057925304 hasConceptScore W2057925304C200082930 @default.
- W2057925304 hasConceptScore W2057925304C2776694085 @default.
- W2057925304 hasConceptScore W2057925304C2778575167 @default.
- W2057925304 hasConceptScore W2057925304C2778684742 @default.
- W2057925304 hasConceptScore W2057925304C2780030769 @default.
- W2057925304 hasConceptScore W2057925304C33923547 @default.
- W2057925304 hasConceptScore W2057925304C3941253 @default.
- W2057925304 hasConceptScore W2057925304C54355233 @default.
- W2057925304 hasConceptScore W2057925304C55493867 @default.
- W2057925304 hasConceptScore W2057925304C62520636 @default.
- W2057925304 hasConceptScore W2057925304C8171440 @default.
- W2057925304 hasConceptScore W2057925304C86803240 @default.
- W2057925304 hasConceptScore W2057925304C98274493 @default.
- W2057925304 hasIssue "8" @default.
- W2057925304 hasLocation W20579253041 @default.
- W2057925304 hasLocation W20579253042 @default.
- W2057925304 hasOpenAccess W2057925304 @default.
- W2057925304 hasPrimaryLocation W20579253041 @default.
- W2057925304 hasRelatedWork W1531644599 @default.
- W2057925304 hasRelatedWork W1593113033 @default.
- W2057925304 hasRelatedWork W1779172654 @default.
- W2057925304 hasRelatedWork W1996521394 @default.
- W2057925304 hasRelatedWork W2036581844 @default.
- W2057925304 hasRelatedWork W2057925304 @default.
- W2057925304 hasRelatedWork W2088431388 @default.
- W2057925304 hasRelatedWork W2157587739 @default.
- W2057925304 hasRelatedWork W3138279926 @default.
- W2057925304 hasRelatedWork W4250091031 @default.
- W2057925304 hasVolume "41" @default.
- W2057925304 isParatext "false" @default.
- W2057925304 isRetracted "false" @default.
- W2057925304 magId "2057925304" @default.
- W2057925304 workType "article" @default.