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• W2057925413 endingPage "e1004004" @default.
• W2057925413 startingPage "e1004004" @default.
• W2057925413 abstract "Vesicular stomatitis virus (VSV) is the prototype for negative sense non segmented (NNS) RNA viruses which include potent human and animal pathogens such as Rabies, Ebola and measles. The polymerases of NNS RNA viruses only initiate transcription at or near the 3' end of their genome template. We measured the dissociation constant of VSV polymerases from their whole genome template to be 20 pM. Given this low dissociation constant, initiation and sustainability of transcription becomes nontrivial. To explore possible mechanisms, we simulated the first hour of transcription using Monte Carlo methods and show that a one-time initial dissociation of all polymerases during entry is not sufficient to sustain transcription. We further show that efficient transcription requires a sliding mechanism for non-transcribing polymerases and can be realized with different polymerase-polymerase interactions and distinct template topologies. In conclusion, we highlight a model in which collisions between transcribing and sliding non-transcribing polymerases result in release of the non-transcribing polymerases allowing for redistribution of polymerases between separate templates during transcription and suggest specific experiments to further test these mechanisms." @default.
• W2057925413 created "2016-06-24" @default.
• W2057925413 creator A5019909886 @default.
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• W2057925413 date "2014-12-11" @default.
• W2057925413 modified "2023-10-16" @default.
• W2057925413 title "Vesicular Stomatitis Virus Polymerase's Strong Affinity to Its Template Suggests Exotic Transcription Models" @default.
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• W2057925413 doi "https://doi.org/10.1371/journal.pcbi.1004004" @default.
• W2057925413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4263359" @default.
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• W2057925413 hasPublicationYear "2014" @default.
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