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- W2057928052 abstract "Tardive dyskinesia seems to occur as a result of diminished cholinergic and enhanced dopaminergic activity in the striatum. Meclofenoxate has been shown to increase cerebral cholinergic activity. To ameliorate the tardive dyskinesia, meclofenoxate was given orally, 600–1200 mg/day, for 6–12 weeks. The effects of the drug were evaluated by scoring the degree of involuntary movement. Among 11 subjects with tardive dyskinesia or dystonia, 4 improved markedly, 1 moderately, 2 slightly, and there was no improvement in 4. One patient with subacute oral dyskinesia, induced by administration of neuroleptics for 1 month, improved markedly. The possibility that meclofenoxate may be effective in dealing with dyskinesias that are induced by neuroleptics warrants further attention." @default.
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- W2057928052 date "1986-02-01" @default.
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- W2057928052 title "Meclofenoxate therapy in tardive dyskinesia: A preliminary report" @default.
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- W2057928052 doi "https://doi.org/10.1016/0006-3223(86)90142-3" @default.
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