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• W2057938567 abstract "Dear Sir We report a Klinefelter syndrome case which progressively developed schizophrenia at age 32. We suprisingly observed many clinical aspects typical of female schizopherenia. Studying the published literature concerning Klinefelter and schizophrenia, we noticed that these female clinical features were frequently reported. We would like to emphasise the importance of clinical and biologogical research of schizophrenia in Klinefelter syndrome in order to analyse the impact of hormonal status in the genesis of schizophrenia. The 32-year-old man was an office worker for 7 years, with an active social life. The patient had many obsessive sexual concerns for two years, but was never examined by a practitioner. He suddenly shut himself in at home, overwhelmed by sexual and agressive ideas. He stopped working because of florid paranoid delusions, with sexual concerns and affective ambivalence. He attempted suicide some days before hospitalization. The clinical examination showed a few symptoms of dissociative features which were resolved within 3 weeks, as positive symptoms, by a single antipsychotic (Haloperidol ®, 15 milligrams by day). The patient has a Klinefelter syndrome (XXY), which was confirmed by a karyotype performed at age 21. We sourced 30 articles through Medline ® that described the clinical specificities of 42 cases of schizophrenia in Klinefelter syndrome. These articles (e.g. Mizukami et al., 1989) showed consistently that the Klinefelter syndrome with schizophrenia has a late age at onset (average-34.4 years, standard deviation = 11.9), a predominence of positive symptoms (60% of cases with described hallucinations), and rarely poor outcomes (one case published). Furthermore, the distribution of age at onset of published schizophrenic Klinefelter is superimposable to the distribution of female schizophrenia, with a blunted peak at age 25, and with a second peak of onset after 40 years. We compared the distribution of ages at onset of these published schizophrenic Klinefelter with a large population of schizophrenic patients from a prevalence study which described gender and familial history of schizophrenia (Gorwood et al., 1995). We thus confirmed that schizophrenic Klinefelter have the same ages at onset than female schizophrenics (average=31.4, standard deviat ion=l l .8 ) (t=2.9, df=356, p=0.13), and different from male schizophrenic (average = 27.8, standard deviation = 9.7) (t = 4.1, df = 396, p < 0.001). Furthermore, the average ages at onset of schizophrenic Klinefelter were more of the type of sporadic female with schizophrenia (t = 0.9, df= 276, p=0.37) than familial female with schizophrenia (t = 3.1, df= 111, p = 0.002). The role of oestradiol in the delay of ages at onset may have been misevaluated since the delay in ages at onset appears (Lewis, 1992) to be similar" @default.
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• W2057938567 date "1997-02-01" @default.
• W2057938567 modified "2023-10-16" @default.
• W2057938567 title "The impact of oestradiol on ages at onset in schizophrenia reevaluated through klinefelter syndrome" @default.
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• W2057938567 doi "https://doi.org/10.1016/s0920-9964(96)00081-3" @default.
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