FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057942504> ?p ?o ?g. }

• W2057942504 endingPage "1893" @default.
• W2057942504 startingPage "1885" @default.
• W2057942504 abstract "Abstract Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells in the bone marrow caused primarily by failure of normal homeostatic mechanisms to prevent the expansion of postgerminal center plasma cells. We have examined the molecular mechanisms that promote the survival of MM cells and have identified a key role for myeloid cell factor–1 (Mcl-1), an antiapoptotic member of the Bcl-2 family. These experiments were initiated by the observation that MM cells were exquisitely sensitive to culture in the presence of actinomycin D: caspase activation occurred within 3 hours of treatment and cells were not protected by interleukin-6, the main MM cell growth and survival factor. Actinomycin D–induced apoptosis was blocked by proteasome inhibitors, suggesting that a labile protein was required for MM cell survival. Further analysis demonstrated that Mcl-1 was likely to be the labile factor governing MM cell survival. Mcl-1 protein levels decreased rapidly after culture in the presence of actinomycin D in concordance with effector caspase activation, but addition of proteasome inhibitors reversed the loss of Mcl-1 and maintained cell viability. The levels of other antiapoptotic proteins, including Bcl-2 and members of the inhibitors-of-apoptosis family, were unaffected by these interventions. Furthermore, Mcl-1 antisense oligonucleotides caused a rapid down-regulation of Mcl-1 protein levels and the coincident induction of apoptosis, whereas overexpression of Mcl-1 delayed actinomycin D–induced apoptosis with kinetics that correlated with expression levels of Mcl-1. These data indicate that Mcl-1 expression is required for the survival of MM cells and may represent an important target for future therapeutics." @default.
• W2057942504 created "2016-06-24" @default.
• W2057942504 creator A5046719320 @default.
• W2057942504 creator A5046881277 @default.
• W2057942504 creator A5081624401 @default.
• W2057942504 date "2002-03-15" @default.
• W2057942504 modified "2023-09-30" @default.
• W2057942504 title "Myeloid cell factor–1 is a critical survival factor for multiple myeloma" @default.
• W2057942504 cites W1482905183 @default.
• W2057942504 cites W1484532115 @default.
• W2057942504 cites W1512072225 @default.
• W2057942504 cites W1520422891 @default.
• W2057942504 cites W1528751727 @default.
• W2057942504 cites W1533153036 @default.
• W2057942504 cites W1544851750 @default.
• W2057942504 cites W1616649922 @default.
• W2057942504 cites W1777794242 @default.
• W2057942504 cites W1779691448 @default.
• W2057942504 cites W1944291718 @default.
• W2057942504 cites W1964617786 @default.
• W2057942504 cites W1973363947 @default.
• W2057942504 cites W1974018903 @default.
• W2057942504 cites W1985804036 @default.
• W2057942504 cites W1988605844 @default.
• W2057942504 cites W1991985869 @default.
• W2057942504 cites W1998500540 @default.
• W2057942504 cites W2000894919 @default.
• W2057942504 cites W2006519535 @default.
• W2057942504 cites W2007000374 @default.
• W2057942504 cites W2007119824 @default.
• W2057942504 cites W2016548691 @default.
• W2057942504 cites W2017755619 @default.
• W2057942504 cites W2019665501 @default.
• W2057942504 cites W2020286569 @default.
• W2057942504 cites W2020329201 @default.
• W2057942504 cites W2020891498 @default.
• W2057942504 cites W2031929368 @default.
• W2057942504 cites W2034269086 @default.
• W2057942504 cites W2036822121 @default.
• W2057942504 cites W2042629507 @default.
• W2057942504 cites W2048463752 @default.
• W2057942504 cites W2051219590 @default.
• W2057942504 cites W2053632669 @default.
• W2057942504 cites W2056302775 @default.
• W2057942504 cites W2056542145 @default.
• W2057942504 cites W2063374921 @default.
• W2057942504 cites W2066408263 @default.
• W2057942504 cites W2069326426 @default.
• W2057942504 cites W2072493113 @default.
• W2057942504 cites W2072836045 @default.
• W2057942504 cites W2073085164 @default.
• W2057942504 cites W2075262248 @default.
• W2057942504 cites W2081567150 @default.
• W2057942504 cites W2091571321 @default.
• W2057942504 cites W2094985040 @default.
• W2057942504 cites W2098734711 @default.
• W2057942504 cites W2118310862 @default.
• W2057942504 cites W2124532303 @default.
• W2057942504 cites W2132411546 @default.
• W2057942504 cites W2135487116 @default.
• W2057942504 cites W2137022580 @default.
• W2057942504 cites W2137986638 @default.
• W2057942504 cites W2140229412 @default.
• W2057942504 cites W2146643673 @default.
• W2057942504 cites W2147114673 @default.
• W2057942504 cites W2147347134 @default.
• W2057942504 cites W2151034091 @default.
• W2057942504 cites W2158946057 @default.
• W2057942504 cites W2162517036 @default.
• W2057942504 cites W2167523976 @default.
• W2057942504 cites W2262689769 @default.
• W2057942504 cites W2317988456 @default.
• W2057942504 cites W2322349519 @default.
• W2057942504 cites W2335120005 @default.
• W2057942504 cites W3145716452 @default.
• W2057942504 cites W4231333654 @default.
• W2057942504 cites W4253103866 @default.
• W2057942504 cites W43460215 @default.
• W2057942504 cites W53629506 @default.
• W2057942504 doi "https://doi.org/10.1182/blood.v99.6.1885" @default.
• W2057942504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11877256" @default.
• W2057942504 hasPublicationYear "2002" @default.
• W2057942504 type Work @default.
• W2057942504 sameAs 2057942504 @default.
• W2057942504 citedByCount "347" @default.
• W2057942504 countsByYear W20579425042012 @default.
• W2057942504 countsByYear W20579425042013 @default.
• W2057942504 countsByYear W20579425042014 @default.
• W2057942504 countsByYear W20579425042015 @default.
• W2057942504 countsByYear W20579425042016 @default.
• W2057942504 countsByYear W20579425042017 @default.
• W2057942504 countsByYear W20579425042018 @default.
• W2057942504 countsByYear W20579425042019 @default.
• W2057942504 countsByYear W20579425042020 @default.
• W2057942504 countsByYear W20579425042021 @default.
• W2057942504 countsByYear W20579425042022 @default.
• W2057942504 countsByYear W20579425042023 @default.
• W2057942504 crossrefType "journal-article" @default.

• next