FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057954784> ?p ?o ?g. }

• W2057954784 endingPage "6315" @default.
• W2057954784 startingPage "6307" @default.
• W2057954784 abstract "Human rhinovirus 14 (HRV14) is a member of the rhinovirus genus, which belongs to the picornavirus family, which includes clinically and economically important members, such as poliovirus, foot-and-mouth disease virus, and endomyocarditis virus. Capsid stability plays an important role in the viral infection process, in that it needs to be stable enough to move from cell to cell and yet be able to release its genetic material upon the appropriate environmental cues from the host cell. It has been suggested that certain host cell molecules, pocket factors, bind to the WIN drug-binding cavity beneath the canyon floor and provide transient stability to a number of the picornaviruses. To directly test this hypothesis, HRV14 was mutated in (V1188M, C1199W, and V1188M/C1199W) and around (S1223G) the drug-binding pocket. Infectivity, limited proteolysis, and matrix-assisted laser desorption ionization analyses indicate that filling the drug-binding pocket with bulky side chains is not deleterious to the viral life cycle and lends some stabilization to the capsid. In contrast, studies with the S1223G mutant suggest that this mutation at least partially overcomes WIN drug-mediated inhibition of cell attachment and capsid breathing. Finally, HRV16, which is inherently more stable than HRV14 in a number of respects, was found to breathe only at 37 degrees C and did not tolerate stabilizing mutations in the drug-binding cavity. These results suggest that it is the drug-binding cavity itself and not the putative pocket factor that is crucial for the capsid dynamics, which is, in turn, necessary for infection." @default.
• W2057954784 created "2016-06-24" @default.
• W2057954784 creator A5025611258 @default.
• W2057954784 creator A5085559825 @default.
• W2057954784 date "2007-06-15" @default.
• W2057954784 modified "2023-09-23" @default.
• W2057954784 title "Pocket Factors Are Unlikely To Play a Major Role in the Life Cycle of Human Rhinovirus" @default.
• W2057954784 cites W1532713048 @default.
• W2057954784 cites W1544228326 @default.
• W2057954784 cites W1544341349 @default.
• W2057954784 cites W1555112738 @default.
• W2057954784 cites W1556533824 @default.
• W2057954784 cites W1829746528 @default.
• W2057954784 cites W1978236018 @default.
• W2057954784 cites W1982634175 @default.
• W2057954784 cites W1993504995 @default.
• W2057954784 cites W2002672149 @default.
• W2057954784 cites W2003126955 @default.
• W2057954784 cites W2005666320 @default.
• W2057954784 cites W2013539241 @default.
• W2057954784 cites W2020056816 @default.
• W2057954784 cites W2025804775 @default.
• W2057954784 cites W2028521223 @default.
• W2057954784 cites W2034747154 @default.
• W2057954784 cites W2037263249 @default.
• W2057954784 cites W2055511881 @default.
• W2057954784 cites W2056363789 @default.
• W2057954784 cites W2056377011 @default.
• W2057954784 cites W2060520834 @default.
• W2057954784 cites W2065692062 @default.
• W2057954784 cites W2077777819 @default.
• W2057954784 cites W2083385781 @default.
• W2057954784 cites W2084352383 @default.
• W2057954784 cites W2086959611 @default.
• W2057954784 cites W2088534734 @default.
• W2057954784 cites W2107351598 @default.
• W2057954784 cites W2126601685 @default.
• W2057954784 cites W2161455368 @default.
• W2057954784 cites W2170265040 @default.
• W2057954784 cites W2171012694 @default.
• W2057954784 cites W96795676 @default.
• W2057954784 doi "https://doi.org/10.1128/jvi.00441-07" @default.
• W2057954784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1900100" @default.
• W2057954784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428846" @default.
• W2057954784 hasPublicationYear "2007" @default.
• W2057954784 type Work @default.
• W2057954784 sameAs 2057954784 @default.
• W2057954784 citedByCount "28" @default.
• W2057954784 countsByYear W20579547842012 @default.
• W2057954784 countsByYear W20579547842013 @default.
• W2057954784 countsByYear W20579547842015 @default.
• W2057954784 countsByYear W20579547842016 @default.
• W2057954784 countsByYear W20579547842017 @default.
• W2057954784 countsByYear W20579547842018 @default.
• W2057954784 countsByYear W20579547842020 @default.
• W2057954784 countsByYear W20579547842022 @default.
• W2057954784 countsByYear W20579547842023 @default.
• W2057954784 crossrefType "journal-article" @default.
• W2057954784 hasAuthorship W2057954784A5025611258 @default.
• W2057954784 hasAuthorship W2057954784A5085559825 @default.
• W2057954784 hasBestOaLocation W20579547841 @default.
• W2057954784 hasConcept C104317684 @default.
• W2057954784 hasConcept C106358424 @default.
• W2057954784 hasConcept C12554922 @default.
• W2057954784 hasConcept C140704245 @default.
• W2057954784 hasConcept C143065580 @default.
• W2057954784 hasConcept C159047783 @default.
• W2057954784 hasConcept C202878990 @default.
• W2057954784 hasConcept C2522874641 @default.
• W2057954784 hasConcept C25897203 @default.
• W2057954784 hasConcept C2778009244 @default.
• W2057954784 hasConcept C2779278377 @default.
• W2057954784 hasConcept C2779756493 @default.
• W2057954784 hasConcept C54355233 @default.
• W2057954784 hasConcept C67705224 @default.
• W2057954784 hasConcept C86803240 @default.
• W2057954784 hasConcept C95444343 @default.
• W2057954784 hasConceptScore W2057954784C104317684 @default.
• W2057954784 hasConceptScore W2057954784C106358424 @default.
• W2057954784 hasConceptScore W2057954784C12554922 @default.
• W2057954784 hasConceptScore W2057954784C140704245 @default.
• W2057954784 hasConceptScore W2057954784C143065580 @default.
• W2057954784 hasConceptScore W2057954784C159047783 @default.
• W2057954784 hasConceptScore W2057954784C202878990 @default.
• W2057954784 hasConceptScore W2057954784C2522874641 @default.
• W2057954784 hasConceptScore W2057954784C25897203 @default.
• W2057954784 hasConceptScore W2057954784C2778009244 @default.
• W2057954784 hasConceptScore W2057954784C2779278377 @default.
• W2057954784 hasConceptScore W2057954784C2779756493 @default.
• W2057954784 hasConceptScore W2057954784C54355233 @default.
• W2057954784 hasConceptScore W2057954784C67705224 @default.
• W2057954784 hasConceptScore W2057954784C86803240 @default.
• W2057954784 hasConceptScore W2057954784C95444343 @default.
• W2057954784 hasIssue "12" @default.
• W2057954784 hasLocation W20579547841 @default.
• W2057954784 hasLocation W20579547842 @default.
• W2057954784 hasLocation W20579547843 @default.
• W2057954784 hasLocation W20579547844 @default.

• next