Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057960810> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2057960810 abstract "Prostaglandin (PG) D2 was studied to determine the pharmacological effects of this PG on the central nervous system. PGD2 (0.45-4.05 mg/kg) decreased spontaneous locomotor activity in rats by as much as 66% of control, however, the neuromuscular coordination of mice, treated at the same doses of PGD2, was not impaired. PGD2 (0.05-4.05 mg/kg) also increased pentobarbital sleeping time in mice from 42% to 238% of control, in a dose-related manner. PGD2 did not prevent convulsions induced in response to electroshock or pentylenetetrazol. Cats monitored for EEG responses to PGD2 infusion displayed variable sensitivity to different doses (16-3000 microgram) of drug, however, the characteristic response to PGD2 was the conversion from a uniform low voltage, fast wave pattern to high voltage, slow waves. Cats administered PGD2 were sedated and sometimes catatonic, and displayed brief periods of hypotension, bradycardia, diarrhea, analgesia and hyperthermia at higher doses of the drug. Thus, PGD2 possesses sedative properties in rodents and cats and may have a role in the central nervous system." @default.
- W2057960810 created "2016-06-24" @default.
- W2057960810 creator A5018361663 @default.
- W2057960810 creator A5035011605 @default.
- W2057960810 creator A5074824881 @default.
- W2057960810 date "1980-05-01" @default.
- W2057960810 modified "2023-10-14" @default.
- W2057960810 title "PGD2 effects on rodent behavior and EEG patterns in cats" @default.
- W2057960810 cites W1489324100 @default.
- W2057960810 cites W1900262093 @default.
- W2057960810 cites W1977915261 @default.
- W2057960810 cites W1984685897 @default.
- W2057960810 cites W1992152941 @default.
- W2057960810 cites W2010342120 @default.
- W2057960810 cites W2021812882 @default.
- W2057960810 cites W2024385007 @default.
- W2057960810 cites W2030711496 @default.
- W2057960810 cites W2048521649 @default.
- W2057960810 cites W2053828234 @default.
- W2057960810 cites W2077676414 @default.
- W2057960810 cites W2079965703 @default.
- W2057960810 cites W2086977414 @default.
- W2057960810 cites W2093748306 @default.
- W2057960810 cites W2094999898 @default.
- W2057960810 cites W2419941194 @default.
- W2057960810 cites W2914242349 @default.
- W2057960810 cites W4252845429 @default.
- W2057960810 doi "https://doi.org/10.1016/0091-3057(80)90161-6" @default.
- W2057960810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7393969" @default.
- W2057960810 hasPublicationYear "1980" @default.
- W2057960810 type Work @default.
- W2057960810 sameAs 2057960810 @default.
- W2057960810 citedByCount "30" @default.
- W2057960810 countsByYear W20579608102015 @default.
- W2057960810 countsByYear W20579608102019 @default.
- W2057960810 crossrefType "journal-article" @default.
- W2057960810 hasAuthorship W2057960810A5018361663 @default.
- W2057960810 hasAuthorship W2057960810A5035011605 @default.
- W2057960810 hasAuthorship W2057960810A5074824881 @default.
- W2057960810 hasConcept C118552586 @default.
- W2057960810 hasConcept C126322002 @default.
- W2057960810 hasConcept C2775858608 @default.
- W2057960810 hasConcept C2776755955 @default.
- W2057960810 hasConcept C2776819090 @default.
- W2057960810 hasConcept C2777495988 @default.
- W2057960810 hasConcept C2777602617 @default.
- W2057960810 hasConcept C2777953023 @default.
- W2057960810 hasConcept C2778186239 @default.
- W2057960810 hasConcept C2779904517 @default.
- W2057960810 hasConcept C2779949491 @default.
- W2057960810 hasConcept C2780664492 @default.
- W2057960810 hasConcept C42219234 @default.
- W2057960810 hasConcept C71924100 @default.
- W2057960810 hasConcept C84393581 @default.
- W2057960810 hasConcept C98274493 @default.
- W2057960810 hasConceptScore W2057960810C118552586 @default.
- W2057960810 hasConceptScore W2057960810C126322002 @default.
- W2057960810 hasConceptScore W2057960810C2775858608 @default.
- W2057960810 hasConceptScore W2057960810C2776755955 @default.
- W2057960810 hasConceptScore W2057960810C2776819090 @default.
- W2057960810 hasConceptScore W2057960810C2777495988 @default.
- W2057960810 hasConceptScore W2057960810C2777602617 @default.
- W2057960810 hasConceptScore W2057960810C2777953023 @default.
- W2057960810 hasConceptScore W2057960810C2778186239 @default.
- W2057960810 hasConceptScore W2057960810C2779904517 @default.
- W2057960810 hasConceptScore W2057960810C2779949491 @default.
- W2057960810 hasConceptScore W2057960810C2780664492 @default.
- W2057960810 hasConceptScore W2057960810C42219234 @default.
- W2057960810 hasConceptScore W2057960810C71924100 @default.
- W2057960810 hasConceptScore W2057960810C84393581 @default.
- W2057960810 hasConceptScore W2057960810C98274493 @default.
- W2057960810 hasLocation W20579608101 @default.
- W2057960810 hasLocation W20579608102 @default.
- W2057960810 hasOpenAccess W2057960810 @default.
- W2057960810 hasPrimaryLocation W20579608101 @default.
- W2057960810 hasRelatedWork W1974439327 @default.
- W2057960810 hasRelatedWork W2007377895 @default.
- W2057960810 hasRelatedWork W2009856243 @default.
- W2057960810 hasRelatedWork W2025123084 @default.
- W2057960810 hasRelatedWork W2050785801 @default.
- W2057960810 hasRelatedWork W2057960810 @default.
- W2057960810 hasRelatedWork W2073644241 @default.
- W2057960810 hasRelatedWork W2110127181 @default.
- W2057960810 hasRelatedWork W2351566131 @default.
- W2057960810 hasRelatedWork W2422893096 @default.
- W2057960810 isParatext "false" @default.
- W2057960810 isRetracted "false" @default.
- W2057960810 magId "2057960810" @default.
- W2057960810 workType "article" @default.