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- W2057962803 abstract "The rapid dissemination of chloroquine-resistant Plasmodium falciparum in West Africa has been well documented and represents a significant health threat to autochthonous populations. The methodical development of alternative chemotherapeutic agents demands that dispensing new antimalarial drugs (mefloquine, halofantrine, and artemisinin [qinghaosu]) be closely monitored in order to protect their clinical utility. Indeed, mefloquine-resistant strains of P. falciparum have been reported. We present data from experiments in vitro on the innate resistance of P. falciparum isolates to mefloquine as well as a disturbing observation of transient resistance to artemisinin. The implications for the extended efficacy of these new antimalarial drugs are addressed." @default.
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- W2057962803 date "1992-03-01" @default.
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- W2057962803 title "Innate resistance to new antimalarial drugs in Plasmodium falciparum from Nigeria" @default.
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- W2057962803 doi "https://doi.org/10.1016/0035-9203(92)90533-i" @default.
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