FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057967701> ?p ?o ?g. }

• W2057967701 endingPage "654" @default.
• W2057967701 startingPage "647" @default.
• W2057967701 abstract "Endotoxins represent one of the most potent classes of microbial immunoactive components that can cause pulmonary inflammation. The aim of this study was to compare the inflammatory potency of two types of Neisseria meningitidis endotoxins (lipooligosaccharides) in lungs: wild type (hexaacylated, LOS(wt)) and mutant type (pentaacylated, LOS(msbB)), and to determine the importance of MD-2 in endotoxin responses in lungs in vivo. Endotoxin-normoresponsive mice (BALB/c) were exposed to selected doses of penta- and hexaacylated lipooligosaccharides (LOS) by nasal aspiration. Cellular and cytokine/chemokine inflammatory responses in bronchoalveolar lavage were measured at 1-, 4-, 8-, 16-, 24-, and 48-hour time points. MD-2-null mice were exposed to one dose of hexaacylated LOS and inflammatory responses were measured after 4 and 24 hours. Inhalation of hexaacylated LOS resulted in strong inflammatory responses, while pentaacylated LOS was much less potent in inducing increases of neutrophils, TNF-alpha, macrophage inflammatory protein-1 alpha, IL-6, granulocyte colony-stimulating factor, and IL-1 beta concentration in bronchoalveolar lavage. Similar kinetics of inflammatory responses in lungs were found in both types of endotoxin exposures. Inhalation of hexaacylated LOS in MD-2-null mice resulted in significantly lower numbers of neutrophils in bronchoalveolar lavage than in normoresponsive mice. Markedly lower inflammatory potency of pentaacylated LOS was observed compared with hexaacylated LOS. Hyporesponsiveness in MD-2-null mice after nasal aspiration of wild-type LOS indicate its essential role in airway responsiveness to endotoxin." @default.
• W2057967701 created "2016-06-24" @default.
• W2057967701 creator A5015680363 @default.
• W2057967701 creator A5023095988 @default.
• W2057967701 creator A5025592571 @default.
• W2057967701 creator A5085640218 @default.
• W2057967701 creator A5085725734 @default.
• W2057967701 date "2008-06-01" @default.
• W2057967701 modified "2023-10-16" @default.
• W2057967701 title "MD-2–Dependent Pulmonary Immune Responses to Inhaled Lipooligosaccharides" @default.
• W2057967701 cites W1967638463 @default.
• W2057967701 cites W1972628791 @default.
• W2057967701 cites W1974508755 @default.
• W2057967701 cites W1980892269 @default.
• W2057967701 cites W1993513102 @default.
• W2057967701 cites W1993540541 @default.
• W2057967701 cites W1997774756 @default.
• W2057967701 cites W2003871329 @default.
• W2057967701 cites W2011097744 @default.
• W2057967701 cites W2016709601 @default.
• W2057967701 cites W2030797708 @default.
• W2057967701 cites W2051596822 @default.
• W2057967701 cites W2052202586 @default.
• W2057967701 cites W2053703827 @default.
• W2057967701 cites W2055883814 @default.
• W2057967701 cites W2066011467 @default.
• W2057967701 cites W2068365384 @default.
• W2057967701 cites W2073578515 @default.
• W2057967701 cites W2078337496 @default.
• W2057967701 cites W2083813609 @default.
• W2057967701 cites W2087867048 @default.
• W2057967701 cites W2108213807 @default.
• W2057967701 cites W2113532250 @default.
• W2057967701 cites W2117471479 @default.
• W2057967701 cites W2117840998 @default.
• W2057967701 cites W2119097227 @default.
• W2057967701 cites W2133001188 @default.
• W2057967701 cites W2134505828 @default.
• W2057967701 cites W2145638464 @default.
• W2057967701 cites W2154013663 @default.
• W2057967701 cites W2161591298 @default.
• W2057967701 cites W2164199170 @default.
• W2057967701 cites W2165767917 @default.
• W2057967701 cites W2282103272 @default.
• W2057967701 cites W28744163 @default.
• W2057967701 cites W3022057079 @default.
• W2057967701 cites W4254186801 @default.
• W2057967701 cites W4293048996 @default.
• W2057967701 doi "https://doi.org/10.1165/rcmb.2007-0418oc" @default.
• W2057967701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2396245" @default.
• W2057967701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18203970" @default.
• W2057967701 hasPublicationYear "2008" @default.
• W2057967701 type Work @default.
• W2057967701 sameAs 2057967701 @default.
• W2057967701 citedByCount "42" @default.
• W2057967701 countsByYear W20579677012012 @default.
• W2057967701 countsByYear W20579677012013 @default.
• W2057967701 countsByYear W20579677012014 @default.
• W2057967701 countsByYear W20579677012015 @default.
• W2057967701 countsByYear W20579677012016 @default.
• W2057967701 countsByYear W20579677012017 @default.
• W2057967701 countsByYear W20579677012018 @default.
• W2057967701 countsByYear W20579677012019 @default.
• W2057967701 countsByYear W20579677012020 @default.
• W2057967701 countsByYear W20579677012021 @default.
• W2057967701 crossrefType "journal-article" @default.
• W2057967701 hasAuthorship W2057967701A5015680363 @default.
• W2057967701 hasAuthorship W2057967701A5023095988 @default.
• W2057967701 hasAuthorship W2057967701A5025592571 @default.
• W2057967701 hasAuthorship W2057967701A5085640218 @default.
• W2057967701 hasAuthorship W2057967701A5085725734 @default.
• W2057967701 hasBestOaLocation W20579677012 @default.
• W2057967701 hasConcept C105702510 @default.
• W2057967701 hasConcept C126322002 @default.
• W2057967701 hasConcept C13373296 @default.
• W2057967701 hasConcept C202751555 @default.
• W2057967701 hasConcept C203014093 @default.
• W2057967701 hasConcept C2776914184 @default.
• W2057967701 hasConcept C2776954882 @default.
• W2057967701 hasConcept C2777714996 @default.
• W2057967701 hasConcept C2777802486 @default.
• W2057967701 hasConcept C2777961210 @default.
• W2057967701 hasConcept C2778690821 @default.
• W2057967701 hasConcept C55493867 @default.
• W2057967701 hasConcept C57992300 @default.
• W2057967701 hasConcept C71924100 @default.
• W2057967701 hasConcept C86803240 @default.
• W2057967701 hasConcept C8891405 @default.
• W2057967701 hasConcept C98274493 @default.
• W2057967701 hasConceptScore W2057967701C105702510 @default.
• W2057967701 hasConceptScore W2057967701C126322002 @default.
• W2057967701 hasConceptScore W2057967701C13373296 @default.
• W2057967701 hasConceptScore W2057967701C202751555 @default.
• W2057967701 hasConceptScore W2057967701C203014093 @default.
• W2057967701 hasConceptScore W2057967701C2776914184 @default.
• W2057967701 hasConceptScore W2057967701C2776954882 @default.
• W2057967701 hasConceptScore W2057967701C2777714996 @default.
• W2057967701 hasConceptScore W2057967701C2777802486 @default.

• next