Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057970912> ?p ?o ?g. }
- W2057970912 endingPage "51" @default.
- W2057970912 startingPage "41" @default.
- W2057970912 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are expressed in the hypothalamus, the gonadotrope cells of the anterior pituitary gland, and the gonads, forming an autocrine-paracrine system in these tissues. Within the pituitary, PACAP functions either alone or synergistically with gonadotropin-releasing hormone (GnRH) to stimulate gonadotropin gene expression and secretion. Our goal was to define the hormonal regulation of pituitary PACAP and PACAP receptor (PAC1) gene expression by dihydrotestosterone (DHT), estradiol, and progesterone alone or in conjunction with GnRH. Treatment of adult male rat pituitary cell cultures with DHT or progesterone augmented GnRH-mediated increase in PACAP messenger RNA (mRNA) levels, but neither had an effect when present alone. Conversely, estradiol treatment blunted PACAP gene expression but did not alter GnRH effects on PACAP expression. Expression of PACAP receptor mRNA was decreased by GnRH treatment, minimally increased by DHT treatment, but not altered by the addition of estradiol or progesterone. DHT and GnRH together blunted PACAP receptor gene expression. Taken together, these results suggest that the activity of the intrapituitary PACAP-PAC1 system is regulated via the complex interaction of gonadal steroids and hypothalamic GnRH." @default.
- W2057970912 created "2016-06-24" @default.
- W2057970912 creator A5029935613 @default.
- W2057970912 creator A5030884448 @default.
- W2057970912 creator A5078266878 @default.
- W2057970912 date "2014-01-01" @default.
- W2057970912 modified "2023-10-16" @default.
- W2057970912 title "Interaction of Gonadal Steroids and Gonadotropin-Releasing Hormone on Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and PACAP Receptor Expression in Cultured Rat Anterior Pituitary Cells" @default.
- W2057970912 cites W1584617526 @default.
- W2057970912 cites W1655087818 @default.
- W2057970912 cites W1964977567 @default.
- W2057970912 cites W1967032043 @default.
- W2057970912 cites W1967174959 @default.
- W2057970912 cites W1970973631 @default.
- W2057970912 cites W1973872148 @default.
- W2057970912 cites W1974184455 @default.
- W2057970912 cites W1976598908 @default.
- W2057970912 cites W1977286827 @default.
- W2057970912 cites W1980038882 @default.
- W2057970912 cites W1981423842 @default.
- W2057970912 cites W1982737947 @default.
- W2057970912 cites W1989760989 @default.
- W2057970912 cites W1996975556 @default.
- W2057970912 cites W2002897814 @default.
- W2057970912 cites W2003054629 @default.
- W2057970912 cites W2006675789 @default.
- W2057970912 cites W2007365317 @default.
- W2057970912 cites W2011585740 @default.
- W2057970912 cites W2017139779 @default.
- W2057970912 cites W2021609514 @default.
- W2057970912 cites W2025414496 @default.
- W2057970912 cites W2028462447 @default.
- W2057970912 cites W2037409444 @default.
- W2057970912 cites W2043090771 @default.
- W2057970912 cites W2043878572 @default.
- W2057970912 cites W2046225717 @default.
- W2057970912 cites W2047102749 @default.
- W2057970912 cites W2047523044 @default.
- W2057970912 cites W2049111053 @default.
- W2057970912 cites W2050047198 @default.
- W2057970912 cites W2053281052 @default.
- W2057970912 cites W2062092601 @default.
- W2057970912 cites W2064082083 @default.
- W2057970912 cites W2071458975 @default.
- W2057970912 cites W2071681547 @default.
- W2057970912 cites W2081443590 @default.
- W2057970912 cites W2090540779 @default.
- W2057970912 cites W2091602148 @default.
- W2057970912 cites W2094650007 @default.
- W2057970912 cites W2095045173 @default.
- W2057970912 cites W2100896177 @default.
- W2057970912 cites W2107757798 @default.
- W2057970912 cites W2109218990 @default.
- W2057970912 cites W2111286539 @default.
- W2057970912 cites W2116598303 @default.
- W2057970912 cites W2119416730 @default.
- W2057970912 cites W2124245112 @default.
- W2057970912 cites W2124518271 @default.
- W2057970912 cites W2134249172 @default.
- W2057970912 cites W2145100037 @default.
- W2057970912 cites W2145659593 @default.
- W2057970912 cites W2146352944 @default.
- W2057970912 cites W2147230329 @default.
- W2057970912 cites W2150630390 @default.
- W2057970912 cites W2153676809 @default.
- W2057970912 cites W2154342609 @default.
- W2057970912 cites W2156979070 @default.
- W2057970912 cites W2159500239 @default.
- W2057970912 cites W2167270131 @default.
- W2057970912 doi "https://doi.org/10.1177/1933719113488454" @default.
- W2057970912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3857764" @default.
- W2057970912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23690336" @default.
- W2057970912 hasPublicationYear "2014" @default.
- W2057970912 type Work @default.
- W2057970912 sameAs 2057970912 @default.
- W2057970912 citedByCount "7" @default.
- W2057970912 countsByYear W20579709122014 @default.
- W2057970912 countsByYear W20579709122015 @default.
- W2057970912 countsByYear W20579709122016 @default.
- W2057970912 countsByYear W20579709122020 @default.
- W2057970912 crossrefType "journal-article" @default.
- W2057970912 hasAuthorship W2057970912A5029935613 @default.
- W2057970912 hasAuthorship W2057970912A5030884448 @default.
- W2057970912 hasAuthorship W2057970912A5078266878 @default.
- W2057970912 hasBestOaLocation W20579709122 @default.
- W2057970912 hasConcept C118303440 @default.
- W2057970912 hasConcept C126322002 @default.
- W2057970912 hasConcept C128240485 @default.
- W2057970912 hasConcept C134018914 @default.
- W2057970912 hasConcept C170493617 @default.
- W2057970912 hasConcept C185592680 @default.
- W2057970912 hasConcept C197012351 @default.
- W2057970912 hasConcept C2777003273 @default.
- W2057970912 hasConcept C2777658017 @default.
- W2057970912 hasConcept C2778575703 @default.
- W2057970912 hasConcept C2778782382 @default.
- W2057970912 hasConcept C2778894405 @default.
- W2057970912 hasConcept C2779029589 @default.