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• W2057973025 endingPage "278" @default.
• W2057973025 startingPage "272" @default.
• W2057973025 abstract "Anticancer drug dosages that specify the maximum dose and minimum dosing interval that are tolerated in a population of dogs are commonly recommended. Because the differences between the effective and toxic doses of most cancer chemotherapeutics is slight, it is important to achieve therapeutic concentrations in tumor tissues at the same time that concentrations in nontarget tissues are minimized. In order to determine the dosage regimen that will most likely accomplish these goals, similar drug concentrations must be achieved in all patients dosed according to a specific regimen. Dosing based on body surface area (BSA) is generally used in an effort to normalize drug concentrations. This is because it is well recognized that measures of many physiologic parameters that are responsible for drug disposition, including renal function and energy expenditure, can be normalized by use of BSA. However, there is substantial evidence that drug disposition is not always proportional to BSA. Differences in distribution, metabolism, and excretion pathways may preclude dose extrapolation among species or among individuals within a species based on BSA. Moreover, genetic differences in drug metabolism are well recognized in humans and in laboratory animals, and it is likely that similar differences exist among breeds of dogs. A review of the pharmacokinetic disposition of several cancer chemotherapeutics suggests that studies are needed to determine the most effective method to achieve equivalent anticancer drug concentrations in diverse veterinary patients." @default.
• W2057973025 created "2016-06-24" @default.
• W2057973025 creator A5078395410 @default.
• W2057973025 creator A5084711186 @default.
• W2057973025 date "1998-07-01" @default.
• W2057973025 modified "2023-09-26" @default.
• W2057973025 title "Use of Body Surface Area to Calculate Chemotherapeutic Drug Dose in Dogs: II. Limitations Imposed by Pharmacokinetic Factors" @default.
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• W2057973025 doi "https://doi.org/10.1111/j.1939-1676.1998.tb02122.x" @default.
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• W2057973025 hasPublicationYear "1998" @default.
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