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• W2057977152 abstract "Abstract Background In Drosophila , all the 64 clonally derived spermatocytes differentiate in syncytium inside two somatic-origin cyst cells. They elongate to form slender spermatids, which are individualized and then released into the seminal vesicle. During individualization, differentiating spermatids are organized in a tight bundle inside the cyst, which is expected to play an important role in sperm selection. However, actual significance of this process and its underlying mechanism are unclear. Results We show that dynamic F-actin-based processes extend from the head cyst cell at the start of individualization, filling the interstitial space at the rostral ends of the maturing spermatid bundle. In addition to actin, these structures contained lamin, beta-catenin, dynamin, myosin VI and several other filopodial components. Further, pharmacological and genetic analyses showed that cytoskeletal stability and dynamin function are essential for their maintenance. Disruption of these F-actin based processes was associated with spermatid bundle disassembly and premature sperm release inside the testis. Conclusion Altogether, our data suggests that the head cyst cell adheres to the maturing spermatid heads through F-actin-based extensions, thus maintaining them in a tight bundle. This is likely to regulate mature sperm release into the seminal vesicle. Overall, this process bears resemblance to mammalian spermiation." @default.
• W2057977152 created "2016-06-24" @default.
• W2057977152 creator A5017185327 @default.
• W2057977152 creator A5070288242 @default.
• W2057977152 creator A5077599963 @default.
• W2057977152 date "2009-05-05" @default.
• W2057977152 modified "2023-10-01" @default.
• W2057977152 title "F-actin-based extensions of the head cyst cell adhere to the maturing spermatids to maintain them in a tight bundle and prevent their premature release in Drosophila testis" @default.
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• W2057977152 doi "https://doi.org/10.1186/1741-7007-7-19" @default.
• W2057977152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2683793" @default.
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