FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057988901> ?p ?o ?g. }

• W2057988901 endingPage "188" @default.
• W2057988901 startingPage "178" @default.
• W2057988901 abstract "Motor symptoms in Parkinson's disease (PD) are associated with complex changes of firing properties in basal ganglia output neurons (BGON). The abnormalities are generally attributed to altered synaptic input and potential post-synaptic mechanisms are currently unknown. Our cell-type selective transcriptome analyses of BGON in the rat 6-hydroxydopamine (6-OHDA) model of PD identified the ion channel HCN3 as a likely contributor to altered neuronal excitability. Quantitative PCR experiments confirmed the HCN3 upregulation in the rat and mouse 6-OHDA models and also demonstrated selectivity of the effect for HCN3. In accordance with the mRNA expression data, in vitro whole cell patch-clamp recordings in BGON showed increased HCN3 current amplitudes and increased rebound excitability in BGON of 6-OHDA treated rats. These data establish HCN3 up-regulation as a novel candidate mechanism that might contribute to the in vivo changes of electrical activity in basal ganglia output neurons of the parkinsonian brain." @default.
• W2057988901 created "2016-06-24" @default.
• W2057988901 creator A5009380006 @default.
• W2057988901 creator A5027942207 @default.
• W2057988901 creator A5040637844 @default.
• W2057988901 creator A5065127539 @default.
• W2057988901 creator A5065779360 @default.
• W2057988901 creator A5067969904 @default.
• W2057988901 date "2009-04-01" @default.
• W2057988901 modified "2023-10-03" @default.
• W2057988901 title "Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons" @default.
• W2057988901 cites W106141043 @default.
• W2057988901 cites W1487837909 @default.
• W2057988901 cites W1510554078 @default.
• W2057988901 cites W1553401382 @default.
• W2057988901 cites W1580411261 @default.
• W2057988901 cites W1768450208 @default.
• W2057988901 cites W1776149394 @default.
• W2057988901 cites W1791046118 @default.
• W2057988901 cites W1823302046 @default.
• W2057988901 cites W1824904986 @default.
• W2057988901 cites W1915840267 @default.
• W2057988901 cites W1970994015 @default.
• W2057988901 cites W1972847465 @default.
• W2057988901 cites W1976452441 @default.
• W2057988901 cites W1976965902 @default.
• W2057988901 cites W1984286247 @default.
• W2057988901 cites W1987971960 @default.
• W2057988901 cites W1988080361 @default.
• W2057988901 cites W1992032377 @default.
• W2057988901 cites W1998850305 @default.
• W2057988901 cites W2016696802 @default.
• W2057988901 cites W2017948121 @default.
• W2057988901 cites W2018191142 @default.
• W2057988901 cites W2020505352 @default.
• W2057988901 cites W2022219891 @default.
• W2057988901 cites W2022520344 @default.
• W2057988901 cites W2023001234 @default.
• W2057988901 cites W2025936719 @default.
• W2057988901 cites W2037340204 @default.
• W2057988901 cites W2041320154 @default.
• W2057988901 cites W2043535426 @default.
• W2057988901 cites W2046361830 @default.
• W2057988901 cites W2048455381 @default.
• W2057988901 cites W2054498084 @default.
• W2057988901 cites W2060588252 @default.
• W2057988901 cites W2070093918 @default.
• W2057988901 cites W2076917693 @default.
• W2057988901 cites W2081417966 @default.
• W2057988901 cites W2092262479 @default.
• W2057988901 cites W2094459745 @default.
• W2057988901 cites W2094516452 @default.
• W2057988901 cites W2098272988 @default.
• W2057988901 cites W2099859528 @default.
• W2057988901 cites W2100068597 @default.
• W2057988901 cites W2102160264 @default.
• W2057988901 cites W2103534508 @default.
• W2057988901 cites W2104136423 @default.
• W2057988901 cites W2113908640 @default.
• W2057988901 cites W2114241875 @default.
• W2057988901 cites W2114362693 @default.
• W2057988901 cites W2115765119 @default.
• W2057988901 cites W2118621245 @default.
• W2057988901 cites W2123106337 @default.
• W2057988901 cites W2145065776 @default.
• W2057988901 cites W2145899551 @default.
• W2057988901 cites W2146454587 @default.
• W2057988901 cites W2158620349 @default.
• W2057988901 cites W2161126622 @default.
• W2057988901 cites W2164158899 @default.
• W2057988901 cites W2165340969 @default.
• W2057988901 cites W2171502806 @default.
• W2057988901 cites W2171569887 @default.
• W2057988901 cites W2171601518 @default.
• W2057988901 cites W2210895667 @default.
• W2057988901 doi "https://doi.org/10.1016/j.nbd.2009.01.007" @default.
• W2057988901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19320057" @default.
• W2057988901 hasPublicationYear "2009" @default.
• W2057988901 type Work @default.
• W2057988901 sameAs 2057988901 @default.
• W2057988901 citedByCount "11" @default.
• W2057988901 countsByYear W20579889012013 @default.
• W2057988901 countsByYear W20579889012014 @default.
• W2057988901 countsByYear W20579889012015 @default.
• W2057988901 countsByYear W20579889012016 @default.
• W2057988901 countsByYear W20579889012019 @default.
• W2057988901 countsByYear W20579889012022 @default.
• W2057988901 crossrefType "journal-article" @default.
• W2057988901 hasAuthorship W2057988901A5009380006 @default.
• W2057988901 hasAuthorship W2057988901A5027942207 @default.
• W2057988901 hasAuthorship W2057988901A5040637844 @default.
• W2057988901 hasAuthorship W2057988901A5065127539 @default.
• W2057988901 hasAuthorship W2057988901A5065779360 @default.
• W2057988901 hasAuthorship W2057988901A5067969904 @default.
• W2057988901 hasConcept C104317684 @default.
• W2057988901 hasConcept C126322002 @default.
• W2057988901 hasConcept C127561419 @default.
• W2057988901 hasConcept C147944092 @default.

• next