Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057992606> ?p ?o ?g. }
- W2057992606 endingPage "22" @default.
- W2057992606 startingPage "11" @default.
- W2057992606 abstract "Werner syndrome (WS) is a human autosomal recessive genetic instability and cancer predisposition syndrome with features of premature aging. Several genetically determined mouse models of WS have been generated, however, none develops features of premature aging or an elevated risk of neoplasia unless additional genetic perturbations are introduced. In order to determine whether differences in cellular phenotype could explain the discrepant phenotypes of Wrn-/- mice and WRN-deficient humans, we compared the cellular phenotype of newly derived Wrn-/- mouse primary fibroblasts with previous analyses of primary and transformed fibroblasts from WS patients and with newly derived, WRN-depleted human primary fibroblasts. These analyses confirmed previously reported cellular phenotypes of WRN-mutant and WRN-deficient human fibroblasts, and demonstrated that the human WRN-deficient cellular phenotype can be detected in cells grown in 5% or in 20% oxygen. In contrast, we did not identify prominent cellular phenotypes present in WRN-deficient human cells in Wrn-/- mouse fibroblasts. Our results indicate that human and mouse fibroblasts have different functional requirements for WRN protein, and that the absence of a strong cellular phenotype may in part explain the failure of Wrn-/- mice to develop an organismal phenotype resembling Werner syndrome." @default.
- W2057992606 created "2016-06-24" @default.
- W2057992606 creator A5021947426 @default.
- W2057992606 creator A5034922438 @default.
- W2057992606 creator A5052870601 @default.
- W2057992606 creator A5059964281 @default.
- W2057992606 creator A5061090065 @default.
- W2057992606 creator A5068201446 @default.
- W2057992606 creator A5073566379 @default.
- W2057992606 creator A5090745470 @default.
- W2057992606 date "2010-01-01" @default.
- W2057992606 modified "2023-10-16" @default.
- W2057992606 title "Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase" @default.
- W2057992606 cites W1498241449 @default.
- W2057992606 cites W1529783938 @default.
- W2057992606 cites W1538603370 @default.
- W2057992606 cites W1935801587 @default.
- W2057992606 cites W1940074648 @default.
- W2057992606 cites W1964550937 @default.
- W2057992606 cites W1964881063 @default.
- W2057992606 cites W1966347623 @default.
- W2057992606 cites W1966888005 @default.
- W2057992606 cites W1967336537 @default.
- W2057992606 cites W1967362046 @default.
- W2057992606 cites W1969578702 @default.
- W2057992606 cites W1970285696 @default.
- W2057992606 cites W1970898019 @default.
- W2057992606 cites W1971438029 @default.
- W2057992606 cites W1975817860 @default.
- W2057992606 cites W1977924452 @default.
- W2057992606 cites W1978974430 @default.
- W2057992606 cites W1985775217 @default.
- W2057992606 cites W1987516656 @default.
- W2057992606 cites W1989207556 @default.
- W2057992606 cites W1998000773 @default.
- W2057992606 cites W2000438077 @default.
- W2057992606 cites W2002420019 @default.
- W2057992606 cites W2003745942 @default.
- W2057992606 cites W2004201880 @default.
- W2057992606 cites W2013703669 @default.
- W2057992606 cites W2013988118 @default.
- W2057992606 cites W2017933374 @default.
- W2057992606 cites W2019405732 @default.
- W2057992606 cites W2026766143 @default.
- W2057992606 cites W2029204193 @default.
- W2057992606 cites W2029969982 @default.
- W2057992606 cites W2031346523 @default.
- W2057992606 cites W2032874780 @default.
- W2057992606 cites W2034145167 @default.
- W2057992606 cites W2036301524 @default.
- W2057992606 cites W2040648977 @default.
- W2057992606 cites W2045464664 @default.
- W2057992606 cites W2050228381 @default.
- W2057992606 cites W2056166567 @default.
- W2057992606 cites W2061553377 @default.
- W2057992606 cites W2063070639 @default.
- W2057992606 cites W2064310741 @default.
- W2057992606 cites W2066253067 @default.
- W2057992606 cites W2070449707 @default.
- W2057992606 cites W2077496230 @default.
- W2057992606 cites W2079091392 @default.
- W2057992606 cites W2079101821 @default.
- W2057992606 cites W2082947047 @default.
- W2057992606 cites W2084712319 @default.
- W2057992606 cites W2088175135 @default.
- W2057992606 cites W2092139028 @default.
- W2057992606 cites W2093624810 @default.
- W2057992606 cites W2094556673 @default.
- W2057992606 cites W2094618951 @default.
- W2057992606 cites W2095370504 @default.
- W2057992606 cites W2100973526 @default.
- W2057992606 cites W2107201644 @default.
- W2057992606 cites W2108780052 @default.
- W2057992606 cites W2110522968 @default.
- W2057992606 cites W2110761051 @default.
- W2057992606 cites W2115607640 @default.
- W2057992606 cites W2115944549 @default.
- W2057992606 cites W2116217779 @default.
- W2057992606 cites W2116343025 @default.
- W2057992606 cites W2117529453 @default.
- W2057992606 cites W2118991749 @default.
- W2057992606 cites W2123292607 @default.
- W2057992606 cites W2125628261 @default.
- W2057992606 cites W2129673947 @default.
- W2057992606 cites W2134253949 @default.
- W2057992606 cites W2135413614 @default.
- W2057992606 cites W2137936832 @default.
- W2057992606 cites W2138466316 @default.
- W2057992606 cites W2141011291 @default.
- W2057992606 cites W2142629409 @default.
- W2057992606 cites W2143090029 @default.
- W2057992606 cites W2146274229 @default.
- W2057992606 cites W2153043528 @default.
- W2057992606 cites W2155437022 @default.
- W2057992606 cites W2163819508 @default.
- W2057992606 cites W2164255791 @default.
- W2057992606 cites W2166344257 @default.
- W2057992606 cites W2168496875 @default.