Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057998045> ?p ?o ?g. }
- W2057998045 endingPage "24" @default.
- W2057998045 startingPage "1" @default.
- W2057998045 abstract "Over the past dozen years, the majority of clinical gene therapy trials for inherited genetic diseases and cancer therapy have been performed using murine onco-retrovirus as the gene delivery vector. The earliest systems used were relatively inefficient in both the rates of transduction and expression of the transgene. Formidable obstacles inherent in the cell biology and/or the immunology of the target cell systems limited the efficacy of gene therapy for many target diseases. Development of novel retrovirus gene transfer systems that are in progress have begun to overcome these obstacles. Evidence of this progress is the recent successful functional correction of the immune T and B lymphocyte deficiency in patients with X-linked severe combined immunodeficiency (X-SCID) and adenosine deaminase (ADA)-deficient SCID following onco-retrovirus vector ex vivo transduction of autologous marrow stem cells [Science 296 (2002) 2410; Science 288 (2000) 669; N. Engl. J. Med. 346 (2002) 1185]. These achievements of prolonged clinical benefit from gene therapy were tempered by the finding of insertional mutageneses in two of the treated X-SCID patients [N. Engl. J. Med. 348 (2003) 255]." @default.
- W2057998045 created "2016-06-24" @default.
- W2057998045 creator A5013149726 @default.
- W2057998045 creator A5026466385 @default.
- W2057998045 date "2003-04-01" @default.
- W2057998045 modified "2023-10-03" @default.
- W2057998045 title "Current developments in the design of onco-retrovirus and lentivirus vector systems for hematopoietic cell gene therapy" @default.
- W2057998045 cites W123261661 @default.
- W2057998045 cites W1277925548 @default.
- W2057998045 cites W134011100 @default.
- W2057998045 cites W1492396077 @default.
- W2057998045 cites W1497122445 @default.
- W2057998045 cites W1499919667 @default.
- W2057998045 cites W1535328290 @default.
- W2057998045 cites W1566969252 @default.
- W2057998045 cites W1587940136 @default.
- W2057998045 cites W1589194933 @default.
- W2057998045 cites W1591189766 @default.
- W2057998045 cites W1602110651 @default.
- W2057998045 cites W1603616546 @default.
- W2057998045 cites W1650736497 @default.
- W2057998045 cites W166191009 @default.
- W2057998045 cites W1732481302 @default.
- W2057998045 cites W1750539994 @default.
- W2057998045 cites W1835972708 @default.
- W2057998045 cites W1908249423 @default.
- W2057998045 cites W1931238275 @default.
- W2057998045 cites W1963799836 @default.
- W2057998045 cites W1965200427 @default.
- W2057998045 cites W1965699576 @default.
- W2057998045 cites W1966541023 @default.
- W2057998045 cites W1968223547 @default.
- W2057998045 cites W1969572418 @default.
- W2057998045 cites W1971910773 @default.
- W2057998045 cites W1972636590 @default.
- W2057998045 cites W1973705988 @default.
- W2057998045 cites W1973862460 @default.
- W2057998045 cites W1976445374 @default.
- W2057998045 cites W1977961016 @default.
- W2057998045 cites W1980217798 @default.
- W2057998045 cites W1981150156 @default.
- W2057998045 cites W1982143869 @default.
- W2057998045 cites W1982537658 @default.
- W2057998045 cites W1984567979 @default.
- W2057998045 cites W1984800697 @default.
- W2057998045 cites W1985770615 @default.
- W2057998045 cites W1987059370 @default.
- W2057998045 cites W1987483457 @default.
- W2057998045 cites W1988614032 @default.
- W2057998045 cites W1989815073 @default.
- W2057998045 cites W1989891990 @default.
- W2057998045 cites W1990923023 @default.
- W2057998045 cites W1991735449 @default.
- W2057998045 cites W1997170085 @default.
- W2057998045 cites W1997554349 @default.
- W2057998045 cites W2004477274 @default.
- W2057998045 cites W2006351633 @default.
- W2057998045 cites W2006519535 @default.
- W2057998045 cites W2006765654 @default.
- W2057998045 cites W2008512248 @default.
- W2057998045 cites W2008782587 @default.
- W2057998045 cites W2009761723 @default.
- W2057998045 cites W2011767474 @default.
- W2057998045 cites W2013908437 @default.
- W2057998045 cites W2015456293 @default.
- W2057998045 cites W2015827800 @default.
- W2057998045 cites W2019363099 @default.
- W2057998045 cites W2019508559 @default.
- W2057998045 cites W2021550815 @default.
- W2057998045 cites W2022007751 @default.
- W2057998045 cites W2022197600 @default.
- W2057998045 cites W2022925457 @default.
- W2057998045 cites W2023774843 @default.
- W2057998045 cites W2024875691 @default.
- W2057998045 cites W2025275264 @default.
- W2057998045 cites W2025659537 @default.
- W2057998045 cites W2025690693 @default.
- W2057998045 cites W2027321452 @default.
- W2057998045 cites W2027458871 @default.
- W2057998045 cites W2028277454 @default.
- W2057998045 cites W2030220702 @default.
- W2057998045 cites W2031813404 @default.
- W2057998045 cites W2032678451 @default.
- W2057998045 cites W2035444138 @default.
- W2057998045 cites W2035595162 @default.
- W2057998045 cites W2040051622 @default.
- W2057998045 cites W2044809408 @default.
- W2057998045 cites W2045957511 @default.
- W2057998045 cites W2046992485 @default.
- W2057998045 cites W2047942455 @default.
- W2057998045 cites W2051473632 @default.
- W2057998045 cites W2051903321 @default.
- W2057998045 cites W2052150955 @default.
- W2057998045 cites W2052575262 @default.
- W2057998045 cites W2054261154 @default.
- W2057998045 cites W2054842943 @default.
- W2057998045 cites W2056020011 @default.
- W2057998045 cites W2059731736 @default.