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• W2058001844 abstract "Gene dosage effects have emerged as playing a central role in the pathogenesis of polycystic kidney disease. Yet, how gene dosage can ultimately have an impact on the formation of kidney cysts remains unknown. In this commentary we review the evidence for the role of gene dosage effects versus the 2-hit mutation model in polycystic kidney disease (PKD), and also discuss how gene networks may potentially make intertwined contributions to PKD." @default.
• W2058001844 created "2016-06-24" @default.
• W2058001844 creator A5036656525 @default.
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• W2058001844 date "2014-04-01" @default.
• W2058001844 modified "2023-09-29" @default.
• W2058001844 title "Polycystic kidney disease – where gene dosage counts" @default.
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• W2058001844 doi "https://doi.org/10.12703/p6-24" @default.
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