FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058004212> ?p ?o ?g. }

• W2058004212 endingPage "1496" @default.
• W2058004212 startingPage "1487" @default.
• W2058004212 abstract "Orexin-A (ORX-A) and orexin-B (ORX-B) play critical roles in the regulation of sleep–wakefulness, energy homeostasis, neuroendocrine system and autonomic functions. Although ORXs are also implicated in the reward process, their electrophysiological effects on neurons in the shell of nucleus accumbems (NAcSh) have not been described thoroughly. Therefore we examined the electrophysiological effects of ORXs on rat NAcSh neurons. Whole cell patch clamp recording in vitro revealed that ORX-A and ORX-B depolarize NAcSh neurons in normal and/or tetrodotoxin (TTX)-containing artificial cerebrospinal fluid (ACSF). The depolarization accompanied by a decrease of membrane resistance was concentration-dependent, and there was no significant difference between the two dose–response curves obtained by ORX-A and ORX-B. The ORX-B-induced depolarization was reduced in low-Na+, flufenamic acid-containing, and high-K+ TTX ACSFs, and completely abolished in low-Na+/high-K+ TTX ACSF. An inhibitor of the Na+/Ca2+ exchanger had no effect on the depolarization. The reversal potential obtained from I–V relationships before and during the ORX-B-induced depolarization in low-Na+ TTX ACSF was about −84 mV, and that obtained in TTX ACSF using patch pipettes with Cs+-containing internal solution was about −38 mV. These results suggest that ORXs directly depolarize NAcSh neurons via OX2 receptors and via a dual ionic mechanism including an increase of nonselective cationic conductance and a decrease of K+ conductance, and that NAcSh neurons are involved in the cellular mechanisms through which ORXs participate in the regulation of the reward process as well as feeding and arousal." @default.
• W2058004212 created "2016-06-24" @default.
• W2058004212 creator A5010170854 @default.
• W2058004212 creator A5010918461 @default.
• W2058004212 creator A5033635567 @default.
• W2058004212 creator A5035399792 @default.
• W2058004212 creator A5041909077 @default.
• W2058004212 creator A5054312440 @default.
• W2058004212 date "2009-08-01" @default.
• W2058004212 modified "2023-09-28" @default.
• W2058004212 title "Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: An in vitro study" @default.
• W2058004212 cites W1627229807 @default.
• W2058004212 cites W1915837588 @default.
• W2058004212 cites W1979801486 @default.
• W2058004212 cites W1980656761 @default.
• W2058004212 cites W1983348906 @default.
• W2058004212 cites W1991498364 @default.
• W2058004212 cites W1999331745 @default.
• W2058004212 cites W2002518106 @default.
• W2058004212 cites W2008360236 @default.
• W2058004212 cites W2013655437 @default.
• W2058004212 cites W2017200167 @default.
• W2058004212 cites W2024183517 @default.
• W2058004212 cites W2024348439 @default.
• W2058004212 cites W2026972964 @default.
• W2058004212 cites W2027609687 @default.
• W2058004212 cites W2027740042 @default.
• W2058004212 cites W2028649508 @default.
• W2058004212 cites W2032570188 @default.
• W2058004212 cites W2038474614 @default.
• W2058004212 cites W2039199726 @default.
• W2058004212 cites W2041731336 @default.
• W2058004212 cites W2042965047 @default.
• W2058004212 cites W2055207238 @default.
• W2058004212 cites W2070712548 @default.
• W2058004212 cites W2073909303 @default.
• W2058004212 cites W2092804224 @default.
• W2058004212 cites W2100149588 @default.
• W2058004212 cites W2100750550 @default.
• W2058004212 cites W2102737392 @default.
• W2058004212 cites W2113323008 @default.
• W2058004212 cites W2115902692 @default.
• W2058004212 cites W2117480181 @default.
• W2058004212 cites W2119279851 @default.
• W2058004212 cites W2121147520 @default.
• W2058004212 cites W2122196568 @default.
• W2058004212 cites W2124281635 @default.
• W2058004212 cites W2131498774 @default.
• W2058004212 cites W2134333835 @default.
• W2058004212 cites W2143609607 @default.
• W2058004212 cites W2150132984 @default.
• W2058004212 cites W2165398609 @default.
• W2058004212 cites W2174764226 @default.
• W2058004212 cites W4239324769 @default.
• W2058004212 cites W4244607577 @default.
• W2058004212 doi "https://doi.org/10.1016/j.peptides.2009.04.018" @default.
• W2058004212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19416746" @default.
• W2058004212 hasPublicationYear "2009" @default.
• W2058004212 type Work @default.
• W2058004212 sameAs 2058004212 @default.
• W2058004212 citedByCount "47" @default.
• W2058004212 countsByYear W20580042122012 @default.
• W2058004212 countsByYear W20580042122013 @default.
• W2058004212 countsByYear W20580042122014 @default.
• W2058004212 countsByYear W20580042122015 @default.
• W2058004212 countsByYear W20580042122016 @default.
• W2058004212 countsByYear W20580042122017 @default.
• W2058004212 countsByYear W20580042122018 @default.
• W2058004212 countsByYear W20580042122019 @default.
• W2058004212 countsByYear W20580042122020 @default.
• W2058004212 countsByYear W20580042122021 @default.
• W2058004212 countsByYear W20580042122022 @default.
• W2058004212 countsByYear W20580042122023 @default.
• W2058004212 crossrefType "journal-article" @default.
• W2058004212 hasAuthorship W2058004212A5010170854 @default.
• W2058004212 hasAuthorship W2058004212A5010918461 @default.
• W2058004212 hasAuthorship W2058004212A5033635567 @default.
• W2058004212 hasAuthorship W2058004212A5035399792 @default.
• W2058004212 hasAuthorship W2058004212A5041909077 @default.
• W2058004212 hasAuthorship W2058004212A5054312440 @default.
• W2058004212 hasConcept C118303440 @default.
• W2058004212 hasConcept C12554922 @default.
• W2058004212 hasConcept C147944092 @default.
• W2058004212 hasConcept C169760540 @default.
• W2058004212 hasConcept C170493617 @default.
• W2058004212 hasConcept C181911157 @default.
• W2058004212 hasConcept C185263204 @default.
• W2058004212 hasConcept C185592680 @default.
• W2058004212 hasConcept C2776119998 @default.
• W2058004212 hasConcept C2776552330 @default.
• W2058004212 hasConcept C2776741303 @default.
• W2058004212 hasConcept C2778071365 @default.
• W2058004212 hasConcept C2779680196 @default.
• W2058004212 hasConcept C4141045 @default.
• W2058004212 hasConcept C529278444 @default.
• W2058004212 hasConcept C55493867 @default.
• W2058004212 hasConcept C86803240 @default.
• W2058004212 hasConceptScore W2058004212C118303440 @default.

• next