FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058005554> ?p ?o ?g. }

• W2058005554 endingPage "1070" @default.
• W2058005554 startingPage "1061" @default.
• W2058005554 abstract "Binding of tumor necrosis factor-α (TNF-α) to its transmembrane receptors (TNFRs) mediates proinflammatory, apoptotic and survival responses in several cell types including vascular endothelial cells. Because ectodomain shedding of cell surface molecules can be modified by proteasome activity, we studied in human endothelial cells whether the TNF-α–TNFRs axis can be regulated by the cleavage of their transmembrane forms in a proteasome-dependent manner. We show that proteasome inhibition increases the release of TNF-α and TNFRs from human endothelial cells and decreases their cellular and cell surface expression. This phenomenon involves the transient activation of mitogen-activated protein kinase p42/p44 that triggers the dispersion of TNF-α and TNFRs from their intracellular Golgi-complex-associated pool towards the plasma membrane. This results in their enhanced cleavage by TNF-α converting enzyme (TACE) because it is reduced by synthetic metalloprotease inhibitors, recombinant TIMP-3 and by a dominant negative form of TACE. In the presence of TACE inhibitor, proteasome inhibition increases the cell surface expression of TNFRs and enhances the sensitivity of these cells to the proapoptotic effect of recombinant TNF-α. In conclusion, our data provide evidence that proteasome inhibitors increase TACE-dependent TNFR-shedding in endothelial cells, supporting the use of these molecules in inflammatory disorders. In association with TACE inhibitor, proteasome inhibitors increase the amount of TNFRs at the cell surface and enhance the sensitivity to the proapoptotic effect of TNF-α, which might be of interest in the antitumor therapy." @default.
• W2058005554 created "2016-06-24" @default.
• W2058005554 creator A5005828725 @default.
• W2058005554 creator A5039238937 @default.
• W2058005554 creator A5040627370 @default.
• W2058005554 creator A5041354033 @default.
• W2058005554 creator A5043134621 @default.
• W2058005554 creator A5070086202 @default.
• W2058005554 creator A5086566678 @default.
• W2058005554 date "2005-03-01" @default.
• W2058005554 modified "2023-10-14" @default.
• W2058005554 title "Proteasome inhibition activates the transport and the ectodomain shedding of TNF-α receptors in human endothelial cells" @default.
• W2058005554 cites W1535099280 @default.
• W2058005554 cites W1970001436 @default.
• W2058005554 cites W1970235416 @default.
• W2058005554 cites W1976089952 @default.
• W2058005554 cites W1977846928 @default.
• W2058005554 cites W1979251516 @default.
• W2058005554 cites W1981306008 @default.
• W2058005554 cites W1991638912 @default.
• W2058005554 cites W1992978957 @default.
• W2058005554 cites W1999005566 @default.
• W2058005554 cites W2005491839 @default.
• W2058005554 cites W2007859383 @default.
• W2058005554 cites W2008744347 @default.
• W2058005554 cites W2010467103 @default.
• W2058005554 cites W2010883488 @default.
• W2058005554 cites W2020122783 @default.
• W2058005554 cites W2023912478 @default.
• W2058005554 cites W2026043555 @default.
• W2058005554 cites W2029270045 @default.
• W2058005554 cites W2032638961 @default.
• W2058005554 cites W2036842448 @default.
• W2058005554 cites W2044312475 @default.
• W2058005554 cites W2048781554 @default.
• W2058005554 cites W2052013007 @default.
• W2058005554 cites W2063679628 @default.
• W2058005554 cites W2066284211 @default.
• W2058005554 cites W2067450274 @default.
• W2058005554 cites W2067530043 @default.
• W2058005554 cites W2072265495 @default.
• W2058005554 cites W2073922677 @default.
• W2058005554 cites W2074881372 @default.
• W2058005554 cites W2076233716 @default.
• W2058005554 cites W2078256947 @default.
• W2058005554 cites W2079648786 @default.
• W2058005554 cites W2095013915 @default.
• W2058005554 cites W2097656264 @default.
• W2058005554 cites W2100292336 @default.
• W2058005554 cites W2112190271 @default.
• W2058005554 cites W2119445810 @default.
• W2058005554 cites W2123343744 @default.
• W2058005554 cites W2126514623 @default.
• W2058005554 cites W2131591599 @default.
• W2058005554 cites W2132917966 @default.
• W2058005554 cites W2141653146 @default.
• W2058005554 cites W2164842539 @default.
• W2058005554 cites W2169590701 @default.
• W2058005554 cites W2172938682 @default.
• W2058005554 cites W2264329642 @default.
• W2058005554 cites W2316770035 @default.
• W2058005554 cites W2335735158 @default.
• W2058005554 cites W2345866504 @default.
• W2058005554 cites W2471732700 @default.
• W2058005554 cites W4240812895 @default.
• W2058005554 doi "https://doi.org/10.1242/jcs.01696" @default.
• W2058005554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15731011" @default.
• W2058005554 hasPublicationYear "2005" @default.
• W2058005554 type Work @default.
• W2058005554 sameAs 2058005554 @default.
• W2058005554 citedByCount "18" @default.
• W2058005554 countsByYear W20580055542012 @default.
• W2058005554 countsByYear W20580055542013 @default.
• W2058005554 countsByYear W20580055542014 @default.
• W2058005554 countsByYear W20580055542016 @default.
• W2058005554 countsByYear W20580055542017 @default.
• W2058005554 crossrefType "journal-article" @default.
• W2058005554 hasAuthorship W2058005554A5005828725 @default.
• W2058005554 hasAuthorship W2058005554A5039238937 @default.
• W2058005554 hasAuthorship W2058005554A5040627370 @default.
• W2058005554 hasAuthorship W2058005554A5041354033 @default.
• W2058005554 hasAuthorship W2058005554A5043134621 @default.
• W2058005554 hasAuthorship W2058005554A5070086202 @default.
• W2058005554 hasAuthorship W2058005554A5086566678 @default.
• W2058005554 hasBestOaLocation W20580055541 @default.
• W2058005554 hasConcept C1009742 @default.
• W2058005554 hasConcept C123012128 @default.
• W2058005554 hasConcept C153911025 @default.
• W2058005554 hasConcept C170493617 @default.
• W2058005554 hasConcept C17991360 @default.
• W2058005554 hasConcept C202751555 @default.
• W2058005554 hasConcept C203014093 @default.
• W2058005554 hasConcept C27740335 @default.
• W2058005554 hasConcept C55493867 @default.
• W2058005554 hasConcept C86803240 @default.
• W2058005554 hasConcept C95444343 @default.
• W2058005554 hasConceptScore W2058005554C1009742 @default.
• W2058005554 hasConceptScore W2058005554C123012128 @default.

• next