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- W2058006326 abstract "Percutaneous coronary intervention (PCI) is a strongly recommended method to the treatment of acute coronary syndrome (ACS). However, in patients undergoing PCI, the levels of inflammatory cytokines and markers increased rapidly, such as vascular cell adhesion molecule-1 (VCAM-1), matrix metalloproteinase-9 (MMP-9) [ 1 Patti G. Chello M. Gatto L. et al. Short-term atorvastatin preload reduces levels of adhesion molecules in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Results from the ARMYDA-ACS CAMs (Atorvastatin for Reduction of MYocardial Damage during Angioplasty-Cell Adhesion Molecules) substudy. J Cardiovasc Med (Hagerstown). 2010; 11: 795-800 Crossref PubMed Scopus (19) Google Scholar , 2 Inokubo Y. Hanada H. Ishizaka H. et al. Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome. Am Heart J. 2001; 141: 211-217 Abstract Full Text Full Text PDF PubMed Scopus (263) Google Scholar ]. Abundant data have elucidated clearly the anti-inflammatory effects of statins, which show prompt effects in the therapy of patients with ACS [ 3 Sposito A.C. Chapman M.J. Statin therapy in acute coronary syndromes: mechanistic insight into clinical benefit. Arterioscler Thromb Vasc Biol. 2002; 22: 1524-1534 Crossref PubMed Scopus (142) Google Scholar , 4 Rosenson R.S. Tangney C.C. Antiatherothrombotic properties of statins: implications for cardiovascular event reduction. JAMA. 1998; 279: 1643-1650 Crossref PubMed Scopus (976) Google Scholar ]. So far studies and trials tested the efficacy of high loading dose atorvastatin therapy before PCI in patients with ACS but there were only few trials about rosuvastatin effects. Thus, we designed a prospective randomized study, using high loading dose rosuvastatin before PCI, to observe whether high loading dose rosuvastatin therapy could attenuate inflammation response in a few hours and reduce the incidence of periprocedural myocardial infarction (PMI) and major adverse cardiac events (MACE)." @default.
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- W2058006326 date "2013-09-01" @default.
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- W2058006326 title "The effects and mechanisms of high loading dose rosuvastatin therapy before percutaneous coronary intervention in patients with acute coronary syndrome" @default.
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- W2058006326 doi "https://doi.org/10.1016/j.ijcard.2012.11.032" @default.
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