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- W2058009094 abstract "Integrins are heterodimeric transmembrane receptors regulating cell-cell and cell-extracellular matrix interactions. Of the 24 integrin heterodimers identified in humans, α9β1 integrin is one of the least studied. α9, together with α4, comprise a more recent evolutionary sub-family of integrins that is only found in vertebrates. Since α9 was thought to have similar functions as α4, due to many shared ligands, it was a rather overlooked integrin until recently, when its importance for survival after birth was highlighted upon investigation of the α9 knockout mouse. α9β1 is expressed on a wide variety of cell types, interacts with many ligands for example fibronectin, tenascin-C and ADAM12, and has been shown to have important functions in processes such as cell adhesion and migration, lung development, lymphatic and venous valve development, and in wound healing. This has sparked an interest to investigate α9β1-mediated signaling and its regulation. This review gives an overview of the recent progress in α9β1-mediated biological and pathological processes, and discusses its potential as a target for cancer diagnosis and therapy." @default.
- W2058009094 created "2016-06-24" @default.
- W2058009094 creator A5047986299 @default.
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- W2058009094 creator A5061562078 @default.
- W2058009094 creator A5069744312 @default.
- W2058009094 creator A5076679264 @default.
- W2058009094 date "2012-05-01" @default.
- W2058009094 modified "2023-10-17" @default.
- W2058009094 title "The newcomer in the integrin family: Integrin α9 in biology and cancer" @default.
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