Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058014966> ?p ?o ?g. }
- W2058014966 endingPage "1492" @default.
- W2058014966 startingPage "1485" @default.
- W2058014966 abstract "Sp1 binding sites have been identified in enhancer/promoter regions of several growth and cell cycle regulated genes, and it has been shown that Sp1 is increasingly phosphorylated in G1 phase of the cell cycle. Interactions of Sp1 with proteins involved in control of cell cycle and tumor formation have been reported. Here we show that expression of Sp1 protein predominates in the G1 phase of the cell cycle in epithelial cells. This is achieved by proteasome-dependent degradation. Inhibition of endogeneous Sp1 activity by a dominant-negative Sp1 mutant was associated with a cell cycle arrest in G1 phase, a strongly reduced expression of cyclin D1, the EGF-receptor and increased levels of p27Kip1. We have thus identified Sp1 as an important regulator of the cell cycle in G1 phase." @default.
- W2058014966 created "2016-06-24" @default.
- W2058014966 creator A5015877224 @default.
- W2058014966 creator A5015971118 @default.
- W2058014966 creator A5016038480 @default.
- W2058014966 creator A5035102277 @default.
- W2058014966 creator A5055281308 @default.
- W2058014966 date "2002-02-27" @default.
- W2058014966 modified "2023-10-18" @default.
- W2058014966 title "Sp1 as G1 cell cycle phase specific transcription factor in epithelial cells" @default.
- W2058014966 cites W1228798347 @default.
- W2058014966 cites W1500574190 @default.
- W2058014966 cites W1529783836 @default.
- W2058014966 cites W1550325341 @default.
- W2058014966 cites W1563225650 @default.
- W2058014966 cites W1640455274 @default.
- W2058014966 cites W1753047181 @default.
- W2058014966 cites W1922521877 @default.
- W2058014966 cites W1974391793 @default.
- W2058014966 cites W1981493299 @default.
- W2058014966 cites W1982290796 @default.
- W2058014966 cites W1992901862 @default.
- W2058014966 cites W1995866851 @default.
- W2058014966 cites W2005075550 @default.
- W2058014966 cites W2011301929 @default.
- W2058014966 cites W2037653294 @default.
- W2058014966 cites W2047058509 @default.
- W2058014966 cites W2049435289 @default.
- W2058014966 cites W2056213387 @default.
- W2058014966 cites W2056917849 @default.
- W2058014966 cites W2068663793 @default.
- W2058014966 cites W2070203770 @default.
- W2058014966 cites W2070743354 @default.
- W2058014966 cites W2075939587 @default.
- W2058014966 cites W2082593333 @default.
- W2058014966 cites W2089126365 @default.
- W2058014966 cites W2090221766 @default.
- W2058014966 cites W2090429649 @default.
- W2058014966 cites W2091403769 @default.
- W2058014966 cites W2098412103 @default.
- W2058014966 cites W2104187492 @default.
- W2058014966 cites W2106169455 @default.
- W2058014966 cites W2108966929 @default.
- W2058014966 cites W2112825652 @default.
- W2058014966 cites W2122107270 @default.
- W2058014966 cites W2128739161 @default.
- W2058014966 cites W2130258789 @default.
- W2058014966 cites W2133778193 @default.
- W2058014966 cites W2163931326 @default.
- W2058014966 cites W2169829358 @default.
- W2058014966 cites W2171027260 @default.
- W2058014966 cites W2171031141 @default.
- W2058014966 cites W2315607246 @default.
- W2058014966 cites W4245211617 @default.
- W2058014966 cites W4250698222 @default.
- W2058014966 doi "https://doi.org/10.1038/sj.onc.1205211" @default.
- W2058014966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11896576" @default.
- W2058014966 hasPublicationYear "2002" @default.
- W2058014966 type Work @default.
- W2058014966 sameAs 2058014966 @default.
- W2058014966 citedByCount "106" @default.
- W2058014966 countsByYear W20580149662012 @default.
- W2058014966 countsByYear W20580149662013 @default.
- W2058014966 countsByYear W20580149662014 @default.
- W2058014966 countsByYear W20580149662015 @default.
- W2058014966 countsByYear W20580149662016 @default.
- W2058014966 countsByYear W20580149662017 @default.
- W2058014966 countsByYear W20580149662018 @default.
- W2058014966 countsByYear W20580149662019 @default.
- W2058014966 countsByYear W20580149662020 @default.
- W2058014966 countsByYear W20580149662021 @default.
- W2058014966 countsByYear W20580149662022 @default.
- W2058014966 countsByYear W20580149662023 @default.
- W2058014966 crossrefType "journal-article" @default.
- W2058014966 hasAuthorship W2058014966A5015877224 @default.
- W2058014966 hasAuthorship W2058014966A5015971118 @default.
- W2058014966 hasAuthorship W2058014966A5016038480 @default.
- W2058014966 hasAuthorship W2058014966A5035102277 @default.
- W2058014966 hasAuthorship W2058014966A5055281308 @default.
- W2058014966 hasBestOaLocation W20580149661 @default.
- W2058014966 hasConcept C101762097 @default.
- W2058014966 hasConcept C104317684 @default.
- W2058014966 hasConcept C105696609 @default.
- W2058014966 hasConcept C111936080 @default.
- W2058014966 hasConcept C124320809 @default.
- W2058014966 hasConcept C1491633281 @default.
- W2058014966 hasConcept C150194340 @default.
- W2058014966 hasConcept C152857842 @default.
- W2058014966 hasConcept C153911025 @default.
- W2058014966 hasConcept C16438837 @default.
- W2058014966 hasConcept C199835354 @default.
- W2058014966 hasConcept C25311885 @default.
- W2058014966 hasConcept C27740335 @default.
- W2058014966 hasConcept C2911011838 @default.
- W2058014966 hasConcept C29537977 @default.
- W2058014966 hasConcept C34688535 @default.
- W2058014966 hasConcept C35195891 @default.
- W2058014966 hasConcept C54355233 @default.