FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058020340> ?p ?o ?g. }

• W2058020340 endingPage "1336" @default.
• W2058020340 startingPage "1326" @default.
• W2058020340 abstract "Apoptosis inducing factor (AIF) is a mitochondrial oxidoreductase that scavenges reactive oxygen species under normal conditions. Under certain stresses, such as exposure to N -methyl- N′ -nitro- N′ -nitrosoguanidine (MNNG), AIF is truncated and released from the mitochondria and translocated into the nucleus, where the truncated AIF (tAIF) induces caspase-independent cell death. However, it is unknown how cells decide to kill themselves or operate ways to survive when they encounter stresses that induce the release of tAIF. Here, we demonstrated that USP2 and CHIP contribute to the control of tAIF stability. USP2 deubiquitinated and stabilized tAIF, thus promoting AIF-mediated cell death. In contrast, CHIP ubiquitinated and destabilized tAIF, thus preventing the cell death. Consistently, CHIP-deficient cells showed an increased sensitivity to MNNG. On the other hand, knockdown of USP2 attenuated MNNG-induced cell death. Moreover, exposure to MNNG caused a dramatic decrease in CHIP level, but not that of USP2, concurrent with cell shrinkage and chromatin condensation. These findings indicate that CHIP and USP2 show antagonistic functions in the control of AIF-mediated cell death, and implicate the role of the enzymes as a switch for cells to live or die under stresses that cause tAIF release." @default.
• W2058020340 created "2016-06-24" @default.
• W2058020340 creator A5017051055 @default.
• W2058020340 creator A5018182534 @default.
• W2058020340 creator A5025748633 @default.
• W2058020340 creator A5035882080 @default.
• W2058020340 creator A5054958021 @default.
• W2058020340 creator A5055162846 @default.
• W2058020340 creator A5056147025 @default.
• W2058020340 creator A5063107400 @default.
• W2058020340 creator A5074415492 @default.
• W2058020340 creator A5090730406 @default.
• W2058020340 date "2011-02-04" @default.
• W2058020340 modified "2023-10-06" @default.
• W2058020340 title "Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme" @default.
• W2058020340 cites W1954801073 @default.
• W2058020340 cites W1966928113 @default.
• W2058020340 cites W1967404904 @default.
• W2058020340 cites W1970297715 @default.
• W2058020340 cites W1976545164 @default.
• W2058020340 cites W1984136850 @default.
• W2058020340 cites W1986906983 @default.
• W2058020340 cites W1988860478 @default.
• W2058020340 cites W1992372295 @default.
• W2058020340 cites W1999816037 @default.
• W2058020340 cites W2000080307 @default.
• W2058020340 cites W2000083423 @default.
• W2058020340 cites W2004543547 @default.
• W2058020340 cites W2006905408 @default.
• W2058020340 cites W2020671984 @default.
• W2058020340 cites W2028925334 @default.
• W2058020340 cites W2032413974 @default.
• W2058020340 cites W2037612957 @default.
• W2058020340 cites W2039444414 @default.
• W2058020340 cites W2046196399 @default.
• W2058020340 cites W2046606780 @default.
• W2058020340 cites W2046968483 @default.
• W2058020340 cites W2058291762 @default.
• W2058020340 cites W2059901120 @default.
• W2058020340 cites W2082282275 @default.
• W2058020340 cites W2085641738 @default.
• W2058020340 cites W2086144679 @default.
• W2058020340 cites W2097094654 @default.
• W2058020340 cites W2113361274 @default.
• W2058020340 cites W2118444721 @default.
• W2058020340 cites W2121781216 @default.
• W2058020340 cites W2143460288 @default.
• W2058020340 cites W2146149989 @default.
• W2058020340 cites W2146528609 @default.
• W2058020340 cites W2159650080 @default.
• W2058020340 cites W2160092851 @default.
• W2058020340 cites W2162579949 @default.
• W2058020340 cites W2163537729 @default.
• W2058020340 cites W2166987747 @default.
• W2058020340 doi "https://doi.org/10.1038/cdd.2011.3" @default.
• W2058020340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172096" @default.
• W2058020340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21293491" @default.
• W2058020340 hasPublicationYear "2011" @default.
• W2058020340 type Work @default.
• W2058020340 sameAs 2058020340 @default.
• W2058020340 citedByCount "40" @default.
• W2058020340 countsByYear W20580203402012 @default.
• W2058020340 countsByYear W20580203402013 @default.
• W2058020340 countsByYear W20580203402014 @default.
• W2058020340 countsByYear W20580203402015 @default.
• W2058020340 countsByYear W20580203402016 @default.
• W2058020340 countsByYear W20580203402017 @default.
• W2058020340 countsByYear W20580203402018 @default.
• W2058020340 countsByYear W20580203402019 @default.
• W2058020340 countsByYear W20580203402020 @default.
• W2058020340 countsByYear W20580203402021 @default.
• W2058020340 countsByYear W20580203402022 @default.
• W2058020340 crossrefType "journal-article" @default.
• W2058020340 hasAuthorship W2058020340A5017051055 @default.
• W2058020340 hasAuthorship W2058020340A5018182534 @default.
• W2058020340 hasAuthorship W2058020340A5025748633 @default.
• W2058020340 hasAuthorship W2058020340A5035882080 @default.
• W2058020340 hasAuthorship W2058020340A5054958021 @default.
• W2058020340 hasAuthorship W2058020340A5055162846 @default.
• W2058020340 hasAuthorship W2058020340A5056147025 @default.
• W2058020340 hasAuthorship W2058020340A5063107400 @default.
• W2058020340 hasAuthorship W2058020340A5074415492 @default.
• W2058020340 hasAuthorship W2058020340A5090730406 @default.
• W2058020340 hasBestOaLocation W20580203401 @default.
• W2058020340 hasConcept C102658986 @default.
• W2058020340 hasConcept C104317684 @default.
• W2058020340 hasConcept C134459356 @default.
• W2058020340 hasConcept C172043667 @default.
• W2058020340 hasConcept C185592680 @default.
• W2058020340 hasConcept C190283241 @default.
• W2058020340 hasConcept C25602115 @default.
• W2058020340 hasConcept C31573885 @default.
• W2058020340 hasConcept C55493867 @default.
• W2058020340 hasConcept C62112901 @default.
• W2058020340 hasConcept C86803240 @default.
• W2058020340 hasConcept C95444343 @default.
• W2058020340 hasConcept C98424977 @default.
• W2058020340 hasConceptScore W2058020340C102658986 @default.

• next