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- W2058045138 abstract "T HE AGE-RELATED EYE DISORDER STUDY (AREDS) was designed as a long-term multicenter prospective study of the clinical course of age-related macular degeneration (AMD) and age-related cataract. The primary goal of the study was to generate data progression rates and risk factors for these disorders to increase our understanding of the clinical course of AMD and cataract, generate hypotheses about etiology, and aid in the design of clinical trials for intervention. In addition, 2 clinical trials were included in the design: a high-dose vitamin and mineral trial for AMD and a high-dose vitamin trial for cataract. The AREDS certainly achieved the primary goal of the study. We obtained important natural history data, including rates of progressions for different stages of AMD, providing prognostic information for patients and facilitating the design of subsequent interventional studies. The AREDS refined useful grading schemes for both clinical trials and clinical practice. A treatment regimen for certain patients with AMD was identified and adopted, though acceptance of AREDS recommendations has been tainted by controversy over the data presentation and analysis. While there is continued discussion of the molecular mechanisms underlying the treatment benefit demonstrated for patients with AMD, the AREDS findings have spawned other clinical trials for nonneovascular AMD. These include a followup, AREDS 2, and other interventions to prevent progression. The AREDS generated other observations, including the interaction of cataract and AMD, the reliability of quality of life measures, and the association of AMD and mortality. There have been 24 published manuscripts from AREDS through 2008 and scores of published abstracts and proceedings." @default.
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- W2058045138 date "2009-12-14" @default.
- W2058045138 modified "2023-09-25" @default.
- W2058045138 title "Legacy of the Age-Related Eye Disorder Study" @default.
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- W2058045138 doi "https://doi.org/10.1001/archophthalmol.2009.321" @default.
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