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- W2058045373 abstract "Troxypyrrolidinium, a choline uptake inhibitor, reduced but failed to abolish responses of the rat urinary bladder to electrical stimulation at 1-100 Hz although it reduced acetylcholine output during stimulation at 10 Hz to a level similar to that of spontaneous release. Inhibition of the response to stimulation was more complete at faster rates of stimulation and was partially reversed by choline. Troxypyrrolidinium produced a greater inhibition of the 'tonic' component of the response to electrical stimulation than of the 'phasic' component. Hemicholinium-3 or hyoscine produced a similar selective effect on the 'tonic' component. Hemicholinium-3 also reduced acetylcholine output during electrical stimulation to a similar extent as troxypyrrolidinium but hyoscine increased transmitter output. The results support the concept of a second transmitter in the excitatory innervation of the bladder." @default.
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- W2058045373 title "The effect of troxypyrrolidinium, a choline uptake inhibitor, on the excitatory innervation of the rat urinary bladder" @default.
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- W2058045373 doi "https://doi.org/10.1016/0014-2999(80)90131-4" @default.
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