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- W2058045695 abstract "Sertoli-Leydig cell tumors (SLCTs) represent a rare group of sex-cord stromal tumors of the ovary of unknown pathogenesis. We report a SLCT of intermediate differentiation with peritoneal recurrence and lymph node metastasis 12 months after removal, including cytogenetic analysis by comparative genomic hybridization and fluorescence in situ hybridization, which showed trisomy 8 as sole unbalanced karyotypic aberration. Our results provide evidence that a simple numeric chromosomal abnormality in SLCT may be associated with a malignant phenotype and suggest that the molecular pathogenesis of SLCT may be different from ovarian granulosa-stromal cell tumors. HUM PATHOL 32:559-562. Copyright © 2001 by W.B. Saunders Company" @default.
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- W2058045695 date "2001-05-01" @default.
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- W2058045695 title "Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor" @default.
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- W2058045695 doi "https://doi.org/10.1053/hupa.2001.24316" @default.
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