Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058049102> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2058049102 endingPage "1155" @default.
- W2058049102 startingPage "1148" @default.
- W2058049102 abstract "Poly-gamma-D-glutamic acid from Bacillus licheniformis is a water-soluble, nontoxic, nonimmunogenic exopolymer. Using synthetic linkers, the alpha-carboxylate side chains of PGA were conjugated to an exposed thiol side chain of an antibody F(ab') fragment, Mc109F4. Analysis of the PGA-Mc109F4 conjugate by gel filtration HPLC revealed a mixture of multivalent conjugates. The PGA-Mc109F4 conjugate retained biological activity, but showed a lower binding affinity to target BCL3B3 cells than free Mc109F4 F(ab')(2) by flow cytometry, and a lower efficacy for BCL3B3 growth inhibition than free Mc109F4 F(ab')(2). PGA was also conjugated with the free amino group of glycopeptide antibiotic vancomycin. The PGA-vancomycin conjugate showed slightly lower antibacterial activity than free vancomycin versus susceptible Bacillus subtilis, but slightly higher activity versus intrinsically resistant Leuconostoc mesenteroides." @default.
- W2058049102 created "2016-06-24" @default.
- W2058049102 creator A5067647635 @default.
- W2058049102 creator A5074087478 @default.
- W2058049102 creator A5074774989 @default.
- W2058049102 creator A5084412882 @default.
- W2058049102 date "2003-11-01" @default.
- W2058049102 modified "2023-10-12" @default.
- W2058049102 title "Multivalent Conjugates of Poly-γ-<scp>d</scp>-glutamic Acid from <i>Bacillus licheniformis</i> with Antibody F(ab‘) and Glycopeptide Ligands" @default.
- W2058049102 cites W1551380120 @default.
- W2058049102 cites W1979129905 @default.
- W2058049102 cites W2000303477 @default.
- W2058049102 cites W2015109935 @default.
- W2058049102 cites W2021199477 @default.
- W2058049102 cites W2025751149 @default.
- W2058049102 cites W2075431088 @default.
- W2058049102 cites W4233033951 @default.
- W2058049102 doi "https://doi.org/10.1021/bc020019m" @default.
- W2058049102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14624628" @default.
- W2058049102 hasPublicationYear "2003" @default.
- W2058049102 type Work @default.
- W2058049102 sameAs 2058049102 @default.
- W2058049102 citedByCount "37" @default.
- W2058049102 countsByYear W20580491022012 @default.
- W2058049102 countsByYear W20580491022013 @default.
- W2058049102 countsByYear W20580491022014 @default.
- W2058049102 countsByYear W20580491022015 @default.
- W2058049102 countsByYear W20580491022016 @default.
- W2058049102 countsByYear W20580491022017 @default.
- W2058049102 countsByYear W20580491022018 @default.
- W2058049102 countsByYear W20580491022019 @default.
- W2058049102 countsByYear W20580491022021 @default.
- W2058049102 countsByYear W20580491022022 @default.
- W2058049102 countsByYear W20580491022023 @default.
- W2058049102 crossrefType "journal-article" @default.
- W2058049102 hasAuthorship W2058049102A5067647635 @default.
- W2058049102 hasAuthorship W2058049102A5074087478 @default.
- W2058049102 hasAuthorship W2058049102A5074774989 @default.
- W2058049102 hasAuthorship W2058049102A5084412882 @default.
- W2058049102 hasConcept C134306372 @default.
- W2058049102 hasConcept C137610392 @default.
- W2058049102 hasConcept C185592680 @default.
- W2058049102 hasConcept C197336794 @default.
- W2058049102 hasConcept C2775920511 @default.
- W2058049102 hasConcept C2776527165 @default.
- W2058049102 hasConcept C2777272437 @default.
- W2058049102 hasConcept C2777957631 @default.
- W2058049102 hasConcept C2778980435 @default.
- W2058049102 hasConcept C2779390152 @default.
- W2058049102 hasConcept C2779489039 @default.
- W2058049102 hasConcept C33923547 @default.
- W2058049102 hasConcept C43617362 @default.
- W2058049102 hasConcept C501593827 @default.
- W2058049102 hasConcept C523546767 @default.
- W2058049102 hasConcept C54355233 @default.
- W2058049102 hasConcept C55493867 @default.
- W2058049102 hasConcept C86803240 @default.
- W2058049102 hasConceptScore W2058049102C134306372 @default.
- W2058049102 hasConceptScore W2058049102C137610392 @default.
- W2058049102 hasConceptScore W2058049102C185592680 @default.
- W2058049102 hasConceptScore W2058049102C197336794 @default.
- W2058049102 hasConceptScore W2058049102C2775920511 @default.
- W2058049102 hasConceptScore W2058049102C2776527165 @default.
- W2058049102 hasConceptScore W2058049102C2777272437 @default.
- W2058049102 hasConceptScore W2058049102C2777957631 @default.
- W2058049102 hasConceptScore W2058049102C2778980435 @default.
- W2058049102 hasConceptScore W2058049102C2779390152 @default.
- W2058049102 hasConceptScore W2058049102C2779489039 @default.
- W2058049102 hasConceptScore W2058049102C33923547 @default.
- W2058049102 hasConceptScore W2058049102C43617362 @default.
- W2058049102 hasConceptScore W2058049102C501593827 @default.
- W2058049102 hasConceptScore W2058049102C523546767 @default.
- W2058049102 hasConceptScore W2058049102C54355233 @default.
- W2058049102 hasConceptScore W2058049102C55493867 @default.
- W2058049102 hasConceptScore W2058049102C86803240 @default.
- W2058049102 hasIssue "6" @default.
- W2058049102 hasLocation W20580491021 @default.
- W2058049102 hasLocation W20580491022 @default.
- W2058049102 hasOpenAccess W2058049102 @default.
- W2058049102 hasPrimaryLocation W20580491021 @default.
- W2058049102 hasRelatedWork W2007962325 @default.
- W2058049102 hasRelatedWork W2056392770 @default.
- W2058049102 hasRelatedWork W2068516008 @default.
- W2058049102 hasRelatedWork W2071999944 @default.
- W2058049102 hasRelatedWork W2123702680 @default.
- W2058049102 hasRelatedWork W2170374595 @default.
- W2058049102 hasRelatedWork W2285495012 @default.
- W2058049102 hasRelatedWork W4205757300 @default.
- W2058049102 hasRelatedWork W2144005980 @default.
- W2058049102 hasRelatedWork W2184058138 @default.
- W2058049102 hasVolume "14" @default.
- W2058049102 isParatext "false" @default.
- W2058049102 isRetracted "false" @default.
- W2058049102 magId "2058049102" @default.
- W2058049102 workType "article" @default.