FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058049476> ?p ?o ?g. }

• W2058049476 endingPage "398" @default.
• W2058049476 startingPage "394" @default.
• W2058049476 abstract "Background The insular cortex is a limbic integration region engaged in emotional and cognitive functions. Previously, we found that neuroleptic-naïve subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms. Methods To further investigate insular cortex abnormalities and their functional correlates, we measured insular gray matter volume and cortical surface size, using magnetic resonance images among 30 patients with schizophrenia and a matched control group. The sample was designed to represent a variety of phenomenologic profiles to provide sufficient variance in multiple measures, including severity of illness and exposure to neuroleptics (typical only). Results There were no significant differences in morphology between patients and control subjects; however, among patients, psychotic symptoms were inversely correlated with insular volume, replicating our previous finding in neuroleptic-naïve subjects. Neuroleptic exposure had a specific effect on insular morphology: increasing drug exposure (measured in dose-years) correlated with larger insular volume. Conclusions This effect of neuroleptic exposure might account for the lack of difference in structural measures in this more chronic sample, whereas the initial study on neuroleptic-naïve subjects showed group differences. Further research is needed to investigate the potential relationship between changes in insula volume from neuroleptic exposure and clinical outcome. The insular cortex is a limbic integration region engaged in emotional and cognitive functions. Previously, we found that neuroleptic-naïve subjects had abnormally small insular volumes compared with control subjects, with volume directly related to severity of psychotic symptoms. To further investigate insular cortex abnormalities and their functional correlates, we measured insular gray matter volume and cortical surface size, using magnetic resonance images among 30 patients with schizophrenia and a matched control group. The sample was designed to represent a variety of phenomenologic profiles to provide sufficient variance in multiple measures, including severity of illness and exposure to neuroleptics (typical only). There were no significant differences in morphology between patients and control subjects; however, among patients, psychotic symptoms were inversely correlated with insular volume, replicating our previous finding in neuroleptic-naïve subjects. Neuroleptic exposure had a specific effect on insular morphology: increasing drug exposure (measured in dose-years) correlated with larger insular volume. This effect of neuroleptic exposure might account for the lack of difference in structural measures in this more chronic sample, whereas the initial study on neuroleptic-naïve subjects showed group differences. Further research is needed to investigate the potential relationship between changes in insula volume from neuroleptic exposure and clinical outcome." @default.
• W2058049476 created "2016-06-24" @default.
• W2058049476 creator A5003407101 @default.
• W2058049476 creator A5012501900 @default.
• W2058049476 creator A5017828339 @default.
• W2058049476 creator A5019406329 @default.
• W2058049476 date "2005-02-01" @default.
• W2058049476 modified "2023-09-26" @default.
• W2058049476 title "Insular cortex abnormalities in schizophrenia: Relationship to symptoms and typical neuroleptic exposure" @default.
• W2058049476 cites W161257794 @default.
• W2058049476 cites W1964356197 @default.
• W2058049476 cites W1964366492 @default.
• W2058049476 cites W1969380437 @default.
• W2058049476 cites W1977528289 @default.
• W2058049476 cites W1982847649 @default.
• W2058049476 cites W1990005524 @default.
• W2058049476 cites W1994426412 @default.
• W2058049476 cites W1994851210 @default.
• W2058049476 cites W1995444499 @default.
• W2058049476 cites W2007428019 @default.
• W2058049476 cites W2016382009 @default.
• W2058049476 cites W2017140635 @default.
• W2058049476 cites W2020025999 @default.
• W2058049476 cites W2027196653 @default.
• W2058049476 cites W2034974057 @default.
• W2058049476 cites W2047512214 @default.
• W2058049476 cites W2051147967 @default.
• W2058049476 cites W2057324855 @default.
• W2058049476 cites W2058145151 @default.
• W2058049476 cites W2068417714 @default.
• W2058049476 cites W2073427964 @default.
• W2058049476 cites W2074887737 @default.
• W2058049476 cites W2078964253 @default.
• W2058049476 cites W2079898539 @default.
• W2058049476 cites W2114109265 @default.
• W2058049476 cites W2118248825 @default.
• W2058049476 cites W2128570033 @default.
• W2058049476 cites W2140261180 @default.
• W2058049476 cites W2147563021 @default.
• W2058049476 cites W2153087078 @default.
• W2058049476 cites W2162430077 @default.
• W2058049476 cites W2167212189 @default.
• W2058049476 cites W2320884975 @default.
• W2058049476 cites W2413084273 @default.
• W2058049476 cites W42923129 @default.
• W2058049476 doi "https://doi.org/10.1016/j.biopsych.2004.11.010" @default.
• W2058049476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15705355" @default.
• W2058049476 hasPublicationYear "2005" @default.
• W2058049476 type Work @default.
• W2058049476 sameAs 2058049476 @default.
• W2058049476 citedByCount "52" @default.
• W2058049476 countsByYear W20580494762012 @default.
• W2058049476 countsByYear W20580494762013 @default.
• W2058049476 countsByYear W20580494762014 @default.
• W2058049476 countsByYear W20580494762015 @default.
• W2058049476 countsByYear W20580494762016 @default.
• W2058049476 countsByYear W20580494762017 @default.
• W2058049476 countsByYear W20580494762018 @default.
• W2058049476 countsByYear W20580494762019 @default.
• W2058049476 countsByYear W20580494762020 @default.
• W2058049476 countsByYear W20580494762021 @default.
• W2058049476 crossrefType "journal-article" @default.
• W2058049476 hasAuthorship W2058049476A5003407101 @default.
• W2058049476 hasAuthorship W2058049476A5012501900 @default.
• W2058049476 hasAuthorship W2058049476A5017828339 @default.
• W2058049476 hasAuthorship W2058049476A5019406329 @default.
• W2058049476 hasConcept C104996578 @default.
• W2058049476 hasConcept C118552586 @default.
• W2058049476 hasConcept C126322002 @default.
• W2058049476 hasConcept C15744967 @default.
• W2058049476 hasConcept C169760540 @default.
• W2058049476 hasConcept C2776412080 @default.
• W2058049476 hasConcept C2777348757 @default.
• W2058049476 hasConcept C2779727114 @default.
• W2058049476 hasConcept C2780539906 @default.
• W2058049476 hasConcept C71924100 @default.
• W2058049476 hasConceptScore W2058049476C104996578 @default.
• W2058049476 hasConceptScore W2058049476C118552586 @default.
• W2058049476 hasConceptScore W2058049476C126322002 @default.
• W2058049476 hasConceptScore W2058049476C15744967 @default.
• W2058049476 hasConceptScore W2058049476C169760540 @default.
• W2058049476 hasConceptScore W2058049476C2776412080 @default.
• W2058049476 hasConceptScore W2058049476C2777348757 @default.
• W2058049476 hasConceptScore W2058049476C2779727114 @default.
• W2058049476 hasConceptScore W2058049476C2780539906 @default.
• W2058049476 hasConceptScore W2058049476C71924100 @default.
• W2058049476 hasIssue "4" @default.
• W2058049476 hasLocation W20580494761 @default.
• W2058049476 hasLocation W20580494762 @default.
• W2058049476 hasOpenAccess W2058049476 @default.
• W2058049476 hasPrimaryLocation W20580494761 @default.
• W2058049476 hasRelatedWork W1968854367 @default.
• W2058049476 hasRelatedWork W1991144875 @default.
• W2058049476 hasRelatedWork W2002580993 @default.
• W2058049476 hasRelatedWork W2024922001 @default.
• W2058049476 hasRelatedWork W2074922907 @default.
• W2058049476 hasRelatedWork W2126758870 @default.
• W2058049476 hasRelatedWork W2156014011 @default.

• next