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• W2058049758 abstract "The neurophysiological mechanisms for persisting impairment of motor function after Guillain–Barré syndrome (GBS) were assessed in 37 unselected patients 1–13 years after diagnosis. For evaluation of reinnervation and axonal loss, macroelectromyography (macro-EMG) including measurement of fiber density (FD) was performed. Data from neuropathy symptom score, neuropathy disability score, nerve conduction studies, and quantitative sensory examination were ranked and summed to a neuropathy rank sum score (NRSS). The isokinetic muscle strength at the ankle was measured. Signs of axonal loss with increase of either macro motor unit potential (macro-MUP) amplitude or FD occurred in 76% of patients. The macro-MUP amplitude correlated with muscle strength and with NRSS. Patients with evidence of residual neuropathy had increased macro-MUP amplitude and FD as well as decreased muscle strength compared to patients without evidence of residual neuropathy. We conclude that axonal loss takes place in a substantial number of GBS patients and is associated with permanent muscle weakness caused by insufficient reinnervation. Possible patterns of pathology are discussed in relation to the macro-EMG findings. Muscle Nerve, 2005" @default.
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• W2058049758 date "2004-11-12" @default.
• W2058049758 modified "2023-09-27" @default.
• W2058049758 title "Electrophysiological signs of permanent axonal loss in a follow-up study of patients with Guillain-Barré syndrome" @default.
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• W2058049758 doi "https://doi.org/10.1002/mus.20240" @default.
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