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• W2058050336 abstract "CD40 is a 45- to 50-kilodalton transmembrane glycoprotein expressed on B lymphocytes, epithelial cells, and some carcinoma cell lines. Human resting B lymphocytes entered a state of sustained proliferation when incubated with both the mouse fibroblastic Ltk- cell line that had been transfected with the human Fc receptor (Fc gamma RII/CDw32) and monoclonal antibodies to CD40. In combination with interleukin-4, factor-dependent long-term normal human B cell lines were generated that were consistently negative for Epstein-Barr viral infection. Thus, cross-linking of CD40 is likely to represent an important phenomenon in the clonal expansion of B cells." @default.
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• W2058050336 date "1991-01-04" @default.
• W2058050336 modified "2023-10-17" @default.
• W2058050336 title "Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40" @default.
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• W2058050336 doi "https://doi.org/10.1126/science.1702555" @default.
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