FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058070463> ?p ?o ?g. }

• W2058070463 endingPage "16859" @default.
• W2058070463 startingPage "16849" @default.
• W2058070463 abstract "Group IVα phospholipase A(2) (PLA(2)IVα) is a lipolytic enzyme that catalyzes the hydrolysis of membrane phospholipids to generate precursors of potent inflammatory lipid mediators. Here, the role of PLA(2)IVα in Fc receptor (FcR)-mediated phagocytosis was investigated, demonstrating that PLA(2)IVα is selectively activated upon FcR-mediated phagocytosis in macrophages and that it rapidly translocates to the site of the nascent phagosome. Moreover, pharmacological inhibition of PLA(2)IVα by pyrrophenone reduces particle internalization by up to 50%. In parallel, fibroblasts from PLA(2)IVα knock-out mice overexpressing FcγRIIA and able to internalize IgG-opsonized beads show 50% lower phagocytosis, compared with wild-type cells, and transfection of PLA(2)IVα fully recovers this impaired function. Interestingly, transfection of the catalytically inactive deleted PLA(2)IVα mutant (PLA(2)IVα(1-525)) and point mutant (PLA(2)IVα-S228C) also promotes recovery of this impaired function. Finally, transfection of the PLA(2)IVα C2 domain (which is directly involved in PLA(2)IVα membrane binding), but not of PLA(2)IVα-D43N (which cannot bind to membranes), rescues FcR-mediated phagocytosis. These data unveil a new mechanism of action for PLA(2)IVα, which demonstrates that the membrane binding, and not the enzymatic activity, is required for PLA(2)IVα modulation of FcR-mediated phagocytosis." @default.
• W2058070463 created "2016-06-24" @default.
• W2058070463 creator A5004570232 @default.
• W2058070463 creator A5030120520 @default.
• W2058070463 creator A5034602770 @default.
• W2058070463 creator A5047098934 @default.
• W2058070463 creator A5070957631 @default.
• W2058070463 creator A5080244425 @default.
• W2058070463 creator A5091457300 @default.
• W2058070463 date "2012-05-01" @default.
• W2058070463 modified "2023-10-16" @default.
• W2058070463 title "Phospholipase A2IVα Regulates Phagocytosis Independent of Its Enzymatic Activity" @default.
• W2058070463 cites W1520663173 @default.
• W2058070463 cites W1530740124 @default.
• W2058070463 cites W1544502281 @default.
• W2058070463 cites W1927734345 @default.
• W2058070463 cites W1933321167 @default.
• W2058070463 cites W1963743324 @default.
• W2058070463 cites W1978139515 @default.
• W2058070463 cites W1980358069 @default.
• W2058070463 cites W1992021138 @default.
• W2058070463 cites W1996962180 @default.
• W2058070463 cites W1997764369 @default.
• W2058070463 cites W1999045066 @default.
• W2058070463 cites W2000081794 @default.
• W2058070463 cites W2001887062 @default.
• W2058070463 cites W2002012958 @default.
• W2058070463 cites W2003780876 @default.
• W2058070463 cites W2007187686 @default.
• W2058070463 cites W2012397093 @default.
• W2058070463 cites W2019774786 @default.
• W2058070463 cites W2020052689 @default.
• W2058070463 cites W2021663812 @default.
• W2058070463 cites W2028586486 @default.
• W2058070463 cites W2029315686 @default.
• W2058070463 cites W2029418267 @default.
• W2058070463 cites W2035801474 @default.
• W2058070463 cites W2039639105 @default.
• W2058070463 cites W2042921323 @default.
• W2058070463 cites W2044761397 @default.
• W2058070463 cites W2059344017 @default.
• W2058070463 cites W2060305880 @default.
• W2058070463 cites W2063250965 @default.
• W2058070463 cites W2065752512 @default.
• W2058070463 cites W2070151083 @default.
• W2058070463 cites W2072334722 @default.
• W2058070463 cites W2072519737 @default.
• W2058070463 cites W2073079404 @default.
• W2058070463 cites W2079860336 @default.
• W2058070463 cites W2080974020 @default.
• W2058070463 cites W2082920258 @default.
• W2058070463 cites W2085077492 @default.
• W2058070463 cites W2088927230 @default.
• W2058070463 cites W2090178694 @default.
• W2058070463 cites W2099487882 @default.
• W2058070463 cites W2105753791 @default.
• W2058070463 cites W2120276871 @default.
• W2058070463 cites W2120640870 @default.
• W2058070463 cites W2121966104 @default.
• W2058070463 cites W2130367469 @default.
• W2058070463 cites W2131984340 @default.
• W2058070463 cites W2142812822 @default.
• W2058070463 cites W2157489886 @default.
• W2058070463 cites W2172141211 @default.
• W2058070463 cites W2199074745 @default.
• W2058070463 cites W2264365292 @default.
• W2058070463 cites W27185518 @default.
• W2058070463 cites W31206901 @default.
• W2058070463 cites W4254797493 @default.
• W2058070463 cites W4301205864 @default.
• W2058070463 doi "https://doi.org/10.1074/jbc.m111.309419" @default.
• W2058070463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3351341" @default.
• W2058070463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22393044" @default.
• W2058070463 hasPublicationYear "2012" @default.
• W2058070463 type Work @default.
• W2058070463 sameAs 2058070463 @default.
• W2058070463 citedByCount "21" @default.
• W2058070463 countsByYear W20580704632012 @default.
• W2058070463 countsByYear W20580704632014 @default.
• W2058070463 countsByYear W20580704632015 @default.
• W2058070463 countsByYear W20580704632016 @default.
• W2058070463 countsByYear W20580704632017 @default.
• W2058070463 countsByYear W20580704632018 @default.
• W2058070463 countsByYear W20580704632019 @default.
• W2058070463 countsByYear W20580704632020 @default.
• W2058070463 countsByYear W20580704632021 @default.
• W2058070463 countsByYear W20580704632022 @default.
• W2058070463 countsByYear W20580704632023 @default.
• W2058070463 crossrefType "journal-article" @default.
• W2058070463 hasAuthorship W2058070463A5004570232 @default.
• W2058070463 hasAuthorship W2058070463A5030120520 @default.
• W2058070463 hasAuthorship W2058070463A5034602770 @default.
• W2058070463 hasAuthorship W2058070463A5047098934 @default.
• W2058070463 hasAuthorship W2058070463A5070957631 @default.
• W2058070463 hasAuthorship W2058070463A5080244425 @default.
• W2058070463 hasAuthorship W2058070463A5091457300 @default.
• W2058070463 hasBestOaLocation W20580704631 @default.
• W2058070463 hasConcept C104317684 @default.

• next