FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058074152> ?p ?o ?g. }

• W2058074152 endingPage "15041" @default.
• W2058074152 startingPage "15030" @default.
• W2058074152 abstract "Elongin A performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that has been shown to target Pol II stalled at sites of DNA damage. Here we investigate the mechanism(s) governing conversion of the Elongin complex from its elongation factor to its ubiquitin ligase form. We report the discovery that assembly of the Elongin A ubiquitin ligase is a tightly regulated process. In unstressed cells, Elongin A is predominately present as part of Pol II elongation factor Elongin. Assembly of Elongin A into the ubiquitin ligase is strongly induced by genotoxic stress; by transcriptional stresses that lead to accumulation of stalled Pol II; and by other stimuli, including endoplasmic reticulum and nutrient stress and retinoic acid signaling, that activate Elongin A-dependent transcription. Taken together, our findings shed new light on mechanisms that control the Elongin A ubiquitin ligase and suggest that it may play a role in Elongin A-dependent transcription. Elongin A performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that has been shown to target Pol II stalled at sites of DNA damage. Here we investigate the mechanism(s) governing conversion of the Elongin complex from its elongation factor to its ubiquitin ligase form. We report the discovery that assembly of the Elongin A ubiquitin ligase is a tightly regulated process. In unstressed cells, Elongin A is predominately present as part of Pol II elongation factor Elongin. Assembly of Elongin A into the ubiquitin ligase is strongly induced by genotoxic stress; by transcriptional stresses that lead to accumulation of stalled Pol II; and by other stimuli, including endoplasmic reticulum and nutrient stress and retinoic acid signaling, that activate Elongin A-dependent transcription. Taken together, our findings shed new light on mechanisms that control the Elongin A ubiquitin ligase and suggest that it may play a role in Elongin A-dependent transcription." @default.
• W2058074152 created "2016-06-24" @default.
• W2058074152 creator A5019674632 @default.
• W2058074152 creator A5025487034 @default.
• W2058074152 creator A5026504223 @default.
• W2058074152 creator A5034566006 @default.
• W2058074152 creator A5046711304 @default.
• W2058074152 creator A5054486813 @default.
• W2058074152 creator A5058560687 @default.
• W2058074152 creator A5060208809 @default.
• W2058074152 creator A5067547412 @default.
• W2058074152 creator A5067830488 @default.
• W2058074152 creator A5079392980 @default.
• W2058074152 creator A5087346423 @default.
• W2058074152 date "2015-06-01" @default.
• W2058074152 modified "2023-10-17" @default.
• W2058074152 title "Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses" @default.
• W2058074152 cites W130301589 @default.
• W2058074152 cites W1486005841 @default.
• W2058074152 cites W1553267416 @default.
• W2058074152 cites W1597678601 @default.
• W2058074152 cites W166838764 @default.
• W2058074152 cites W1839206272 @default.
• W2058074152 cites W1972903765 @default.
• W2058074152 cites W1984866675 @default.
• W2058074152 cites W1987322786 @default.
• W2058074152 cites W1988031203 @default.
• W2058074152 cites W1990213691 @default.
• W2058074152 cites W1990299806 @default.
• W2058074152 cites W1993243592 @default.
• W2058074152 cites W1997974981 @default.
• W2058074152 cites W1999895557 @default.
• W2058074152 cites W2000858083 @default.
• W2058074152 cites W2010258457 @default.
• W2058074152 cites W2011162627 @default.
• W2058074152 cites W2018002092 @default.
• W2058074152 cites W2019405732 @default.
• W2058074152 cites W2026465178 @default.
• W2058074152 cites W2031375145 @default.
• W2058074152 cites W2032601646 @default.
• W2058074152 cites W2032677592 @default.
• W2058074152 cites W2038038813 @default.
• W2058074152 cites W2038045924 @default.
• W2058074152 cites W2038894647 @default.
• W2058074152 cites W2044690677 @default.
• W2058074152 cites W2046082575 @default.
• W2058074152 cites W2047050750 @default.
• W2058074152 cites W2047122698 @default.
• W2058074152 cites W2053894359 @default.
• W2058074152 cites W2057354382 @default.
• W2058074152 cites W2058858849 @default.
• W2058074152 cites W2061865657 @default.
• W2058074152 cites W2062114156 @default.
• W2058074152 cites W2068649233 @default.
• W2058074152 cites W2070098827 @default.
• W2058074152 cites W2070372183 @default.
• W2058074152 cites W2074022648 @default.
• W2058074152 cites W2076665343 @default.
• W2058074152 cites W2076713615 @default.
• W2058074152 cites W2078138443 @default.
• W2058074152 cites W2078753112 @default.
• W2058074152 cites W2083960841 @default.
• W2058074152 cites W2088703460 @default.
• W2058074152 cites W2090345852 @default.
• W2058074152 cites W2091192140 @default.
• W2058074152 cites W2092638438 @default.
• W2058074152 cites W2096016231 @default.
• W2058074152 cites W2096778555 @default.
• W2058074152 cites W2098741254 @default.
• W2058074152 cites W2102557954 @default.
• W2058074152 cites W2104400024 @default.
• W2058074152 cites W2108422586 @default.
• W2058074152 cites W2116317104 @default.
• W2058074152 cites W2120740595 @default.
• W2058074152 cites W2120961682 @default.
• W2058074152 cites W2127956308 @default.
• W2058074152 cites W2134178604 @default.
• W2058074152 cites W2135144687 @default.
• W2058074152 cites W2135229538 @default.
• W2058074152 cites W2138976334 @default.
• W2058074152 cites W2140158862 @default.
• W2058074152 cites W2142644202 @default.
• W2058074152 cites W2148330261 @default.
• W2058074152 cites W2154836767 @default.
• W2058074152 cites W2158534339 @default.
• W2058074152 cites W2792152836 @default.
• W2058074152 cites W3022823009 @default.
• W2058074152 doi "https://doi.org/10.1074/jbc.m114.632794" @default.
• W2058074152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4463447" @default.
• W2058074152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25878247" @default.
• W2058074152 hasPublicationYear "2015" @default.
• W2058074152 type Work @default.
• W2058074152 sameAs 2058074152 @default.
• W2058074152 citedByCount "21" @default.
• W2058074152 countsByYear W20580741522016 @default.
• W2058074152 countsByYear W20580741522017 @default.
• W2058074152 countsByYear W20580741522019 @default.
• W2058074152 countsByYear W20580741522020 @default.

• next