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- W2058077141 startingPage "336" @default.
- W2058077141 abstract "In addition to their role in cardiorespiratory regulation, carotid body (CB) chemoreceptors serve as sensors for inflammatory status and as a protective factor during sepsis. However, lipopolysaccharide-induced sepsis (LPS) reduces CB responsiveness to excitatory or depressant stimuli. We tested whether LPS exerts a direct effect on the carotid chemoreceptor pathway, the CB and its sensory ganglion. We determined that the rat CB and nodose-petrosal-jugular ganglion complex (NPJgc) express TLR4, TNF-α and its receptors (TNF-R1 and TNF-R2). LPS administration (15mg/kg intraperitoneally) evoked MyD88-mechanism pathway activation in CB and NPJgc, with NF-κB p65, p38 MAPK, and ERK activation. Consistently, LPS increased TNF-α and TNF-R2. Double-labeling studies showed that the aforementioned pathway occurs in TH-containing glomus cells and NPJgc neurons, components of the chemosensitive neural pathway. Thus, our results suggest that LPS acting directly through TLR4/MyD88-mechanism pathways increases TNF-α and TNF-R2 expression in the carotid chemoreceptor pathway. These results show a novel afferent pathway to the central nervous system during endotoxemia, and could be relevant in understanding sepsis pathophysiology and therapy." @default.
- W2058077141 created "2016-06-24" @default.
- W2058077141 creator A5005555598 @default.
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- W2058077141 creator A5078135059 @default.
- W2058077141 date "2011-03-01" @default.
- W2058077141 modified "2023-10-14" @default.
- W2058077141 title "Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome" @default.
- W2058077141 cites W1487068141 @default.
- W2058077141 cites W1534996404 @default.
- W2058077141 cites W1606537345 @default.
- W2058077141 cites W1632450738 @default.
- W2058077141 cites W1964060067 @default.
- W2058077141 cites W1967904751 @default.
- W2058077141 cites W1968295892 @default.
- W2058077141 cites W1971446180 @default.
- W2058077141 cites W1973720695 @default.
- W2058077141 cites W1975215292 @default.
- W2058077141 cites W1977802882 @default.
- W2058077141 cites W1979803052 @default.
- W2058077141 cites W1988664400 @default.
- W2058077141 cites W1989448739 @default.
- W2058077141 cites W1991511040 @default.
- W2058077141 cites W1993691455 @default.
- W2058077141 cites W1996405087 @default.
- W2058077141 cites W1999325378 @default.
- W2058077141 cites W2001777398 @default.
- W2058077141 cites W2002313056 @default.
- W2058077141 cites W2002751444 @default.
- W2058077141 cites W2011069161 @default.
- W2058077141 cites W2012844837 @default.
- W2058077141 cites W2013138509 @default.
- W2058077141 cites W2018366225 @default.
- W2058077141 cites W2023268846 @default.
- W2058077141 cites W2023813158 @default.
- W2058077141 cites W2024112468 @default.
- W2058077141 cites W2027512930 @default.
- W2058077141 cites W2028635666 @default.
- W2058077141 cites W2030053463 @default.
- W2058077141 cites W2030416235 @default.
- W2058077141 cites W2031551713 @default.
- W2058077141 cites W2032223695 @default.
- W2058077141 cites W2038881573 @default.
- W2058077141 cites W2039544605 @default.
- W2058077141 cites W2045617696 @default.
- W2058077141 cites W2045922822 @default.
- W2058077141 cites W2046833558 @default.
- W2058077141 cites W2047265728 @default.
- W2058077141 cites W2049710822 @default.
- W2058077141 cites W2051720676 @default.
- W2058077141 cites W2057021422 @default.
- W2058077141 cites W2057688664 @default.
- W2058077141 cites W2059130754 @default.
- W2058077141 cites W2061026694 @default.
- W2058077141 cites W2062835892 @default.
- W2058077141 cites W2063196031 @default.
- W2058077141 cites W2064597006 @default.
- W2058077141 cites W2066344875 @default.
- W2058077141 cites W2067875627 @default.
- W2058077141 cites W2069809822 @default.
- W2058077141 cites W2070909415 @default.
- W2058077141 cites W2082177070 @default.
- W2058077141 cites W2086605267 @default.
- W2058077141 cites W2087203965 @default.
- W2058077141 cites W2093312779 @default.
- W2058077141 cites W2095886784 @default.
- W2058077141 cites W2097656264 @default.
- W2058077141 cites W2100605100 @default.
- W2058077141 cites W2102085604 @default.
- W2058077141 cites W2102275259 @default.
- W2058077141 cites W2105625333 @default.
- W2058077141 cites W2123355863 @default.
- W2058077141 cites W2126541456 @default.
- W2058077141 cites W2127981981 @default.
- W2058077141 cites W2128862717 @default.
- W2058077141 cites W2134175058 @default.
- W2058077141 cites W2134268225 @default.
- W2058077141 cites W2140271230 @default.
- W2058077141 cites W2142850882 @default.
- W2058077141 cites W2145407987 @default.
- W2058077141 cites W2146298543 @default.
- W2058077141 cites W2159962709 @default.
- W2058077141 cites W2166997718 @default.
- W2058077141 cites W2168357151 @default.
- W2058077141 cites W2171201258 @default.
- W2058077141 cites W2183579505 @default.
- W2058077141 cites W2184083248 @default.
- W2058077141 cites W2245250143 @default.
- W2058077141 cites W2768146862 @default.
- W2058077141 cites W4243836839 @default.
- W2058077141 cites W4297986321 @default.
- W2058077141 doi "https://doi.org/10.1016/j.resp.2010.12.014" @default.