FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058078081> ?p ?o ?g. }

• W2058078081 endingPage "114" @default.
• W2058078081 startingPage "99" @default.
• W2058078081 abstract "Legionella pneumophila survives within macrophages by evading phagosome–lysosome fusion. To determine whether L. pneumophila resides in an intermediate endosomal compartment or is isolated from the endosomal pathway and to investigate what bacterial factors contribute to establishment of its vacuole, we applied a series of fluorescence microscopy assays. The majority of vacuoles, aged 2.5 min to 4 h containing post-exponential phase (PE) L. pneumophila, appeared to be separate from the endosomal pathway, as judged by the absence of transferrin receptor, LAMP-1, cathepsin D and each of four fluorescent probes used to label the endocytic pathway either before or after infection. In contrast, more than 70% of phagosomes that contained Escherichia coli, polystyrene beads, or exponential phase (E) L. pneumophila matured to phagolysosomes, as judged by co-localization with LAMP-1, cathepsin D and fluorescent endosomal probes. Surprisingly, neither bacterial viability nor the putative Dot/Icm transport complex was absolutely required for vacuole isolation; although phagosomes containing either formalin-killed PE wild-type or live PE dotA or dotB mutant L. pneumophila rapidly accumulated LAMP-1, less than 20% acquired lysosomal cathepsin D or fluorescent endosomal probes. Therefore, a Dot-dependent factor(s) isolates the L. pneumophila phagosome from a LAMP-1-containing compartment, and a formalin-resistant Dot-independent activity inhibits vacuolar accumulation of endocytosed material and delivery to the degradative lysosomes." @default.
• W2058078081 created "2016-06-24" @default.
• W2058078081 creator A5036051855 @default.
• W2058078081 creator A5042400852 @default.
• W2058078081 creator A5065329522 @default.
• W2058078081 date "2001-02-01" @default.
• W2058078081 modified "2023-09-23" @default.
• W2058078081 title "Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages" @default.
• W2058078081 cites W1482870182 @default.
• W2058078081 cites W1602614750 @default.
• W2058078081 cites W1875153536 @default.
• W2058078081 cites W1899626910 @default.
• W2058078081 cites W1933647785 @default.
• W2058078081 cites W1953178180 @default.
• W2058078081 cites W1962752773 @default.
• W2058078081 cites W1963925741 @default.
• W2058078081 cites W1967006803 @default.
• W2058078081 cites W1970935350 @default.
• W2058078081 cites W1973232347 @default.
• W2058078081 cites W1976448169 @default.
• W2058078081 cites W1978100320 @default.
• W2058078081 cites W1980969503 @default.
• W2058078081 cites W1982795035 @default.
• W2058078081 cites W1999924463 @default.
• W2058078081 cites W2025812024 @default.
• W2058078081 cites W2033370501 @default.
• W2058078081 cites W2034083035 @default.
• W2058078081 cites W2041999173 @default.
• W2058078081 cites W2049288737 @default.
• W2058078081 cites W2049456755 @default.
• W2058078081 cites W2054323226 @default.
• W2058078081 cites W2056573022 @default.
• W2058078081 cites W2066974855 @default.
• W2058078081 cites W2070479570 @default.
• W2058078081 cites W2071240790 @default.
• W2058078081 cites W2071990248 @default.
• W2058078081 cites W2080934311 @default.
• W2058078081 cites W2089664448 @default.
• W2058078081 cites W2100957067 @default.
• W2058078081 cites W2104416424 @default.
• W2058078081 cites W2107721036 @default.
• W2058078081 cites W2108100159 @default.
• W2058078081 cites W2110276933 @default.
• W2058078081 cites W2110408216 @default.
• W2058078081 cites W2113068755 @default.
• W2058078081 cites W2114346833 @default.
• W2058078081 cites W2114765873 @default.
• W2058078081 cites W2116240330 @default.
• W2058078081 cites W2116765105 @default.
• W2058078081 cites W2119784689 @default.
• W2058078081 cites W2119878454 @default.
• W2058078081 cites W2122498796 @default.
• W2058078081 cites W2123076427 @default.
• W2058078081 cites W2128066329 @default.
• W2058078081 cites W2130967505 @default.
• W2058078081 cites W2135261981 @default.
• W2058078081 cites W2141902291 @default.
• W2058078081 cites W2144591496 @default.
• W2058078081 cites W2146950688 @default.
• W2058078081 cites W2147251439 @default.
• W2058078081 cites W2150887421 @default.
• W2058078081 cites W2152517932 @default.
• W2058078081 cites W2153356740 @default.
• W2058078081 cites W2155795106 @default.
• W2058078081 cites W2157685329 @default.
• W2058078081 cites W2158802325 @default.
• W2058078081 cites W2158958374 @default.
• W2058078081 cites W2161459142 @default.
• W2058078081 cites W2164620775 @default.
• W2058078081 cites W2167149210 @default.
• W2058078081 cites W2167688671 @default.
• W2058078081 cites W2171821916 @default.
• W2058078081 cites W2296824252 @default.
• W2058078081 cites W32652449 @default.
• W2058078081 cites W348719356 @default.
• W2058078081 cites W4231136244 @default.
• W2058078081 cites W4244780670 @default.
• W2058078081 cites W4247647124 @default.
• W2058078081 cites W4247696439 @default.
• W2058078081 doi "https://doi.org/10.1046/j.1462-5822.2001.00093.x" @default.
• W2058078081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11207624" @default.
• W2058078081 hasPublicationYear "2001" @default.
• W2058078081 type Work @default.
• W2058078081 sameAs 2058078081 @default.
• W2058078081 citedByCount "94" @default.
• W2058078081 countsByYear W20580780812012 @default.
• W2058078081 countsByYear W20580780812013 @default.
• W2058078081 countsByYear W20580780812014 @default.
• W2058078081 countsByYear W20580780812015 @default.
• W2058078081 countsByYear W20580780812016 @default.
• W2058078081 countsByYear W20580780812017 @default.
• W2058078081 countsByYear W20580780812018 @default.
• W2058078081 countsByYear W20580780812019 @default.
• W2058078081 countsByYear W20580780812020 @default.
• W2058078081 countsByYear W20580780812022 @default.
• W2058078081 countsByYear W20580780812023 @default.
• W2058078081 crossrefType "journal-article" @default.
• W2058078081 hasAuthorship W2058078081A5036051855 @default.

• next