Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058078905> ?p ?o ?g. }
- W2058078905 endingPage "208" @default.
- W2058078905 startingPage "179" @default.
- W2058078905 abstract "Members of the transient receptor potential (TRP) family of nonselective cation channels are involved in several pathological and physiological conditions. The search for the molecular targets for naturally occurring substances, especially from plants, allowed the characterization of many TRP channels. In fact, attempts to understand the hot and painful action of the vanillyl group containing compounds capsaicin (from Capsicum sp.) and its ultrapotent analogue resiniferatoxin (RTX, from Euphorbia sp.) led to the cloning of the vanilloid receptor (TRPV1) 7 years ago. TRPV1 is found in sensory fibers and functions as a molecular integrator of several painful stimuli, being especially stimulated during inflammation. Since TRPV1 is involved in several pathological conditions, selective ligands or modulators of this channel are substances of potential interest to treat such diseases. Once again, natural products seem to be also interesting sources of compounds that might be prototype TRPV1 ligands. The cloning of TRPV1 also enabled the discovery of other members of the TRPV family of channels. Similar to TRPV1, these receptors function as molecular detectors of physical and chemical stimuli, such as innocuous and noxious heat, as well as mechanical force. Recently, novel TRP channels sensitive to low temperatures also have been cloned, namely, TRPM8 and TRPA1. Such channels are also activated by naturally occurring substances but knowledge of their involvement in health and disease is in its infancy. In the present review, we focused on the contribution of natural products to the discovery of TRP channels and to the development of novel drugs to treat pathological conditions in which these channels are involved." @default.
- W2058078905 created "2016-06-24" @default.
- W2058078905 creator A5043712906 @default.
- W2058078905 creator A5056242920 @default.
- W2058078905 creator A5075658959 @default.
- W2058078905 creator A5083584375 @default.
- W2058078905 date "2005-05-01" @default.
- W2058078905 modified "2023-10-18" @default.
- W2058078905 title "Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions" @default.
- W2058078905 cites W1488329806 @default.
- W2058078905 cites W1492591187 @default.
- W2058078905 cites W1495409864 @default.
- W2058078905 cites W1511198581 @default.
- W2058078905 cites W1515467954 @default.
- W2058078905 cites W1527988408 @default.
- W2058078905 cites W1545384325 @default.
- W2058078905 cites W1548172758 @default.
- W2058078905 cites W1562645017 @default.
- W2058078905 cites W1570505030 @default.
- W2058078905 cites W1571969265 @default.
- W2058078905 cites W1594758412 @default.
- W2058078905 cites W1775606549 @default.
- W2058078905 cites W1832560920 @default.
- W2058078905 cites W1893308746 @default.
- W2058078905 cites W1952328179 @default.
- W2058078905 cites W1963531856 @default.
- W2058078905 cites W1963777402 @default.
- W2058078905 cites W1964358846 @default.
- W2058078905 cites W1966150192 @default.
- W2058078905 cites W1967253386 @default.
- W2058078905 cites W1967621441 @default.
- W2058078905 cites W1968366571 @default.
- W2058078905 cites W1970629236 @default.
- W2058078905 cites W1972656091 @default.
- W2058078905 cites W1973099290 @default.
- W2058078905 cites W1973377266 @default.
- W2058078905 cites W1973767763 @default.
- W2058078905 cites W1973806783 @default.
- W2058078905 cites W1973913639 @default.
- W2058078905 cites W1976037358 @default.
- W2058078905 cites W1976876550 @default.
- W2058078905 cites W1978097698 @default.
- W2058078905 cites W1978598856 @default.
- W2058078905 cites W1979455808 @default.
- W2058078905 cites W1979895609 @default.
- W2058078905 cites W1980087755 @default.
- W2058078905 cites W1980226134 @default.
- W2058078905 cites W1981659462 @default.
- W2058078905 cites W1981835164 @default.
- W2058078905 cites W1982486909 @default.
- W2058078905 cites W1983594269 @default.
- W2058078905 cites W1983678541 @default.
- W2058078905 cites W1983995786 @default.
- W2058078905 cites W1985030046 @default.
- W2058078905 cites W1985290812 @default.
- W2058078905 cites W1987418164 @default.
- W2058078905 cites W1988239155 @default.
- W2058078905 cites W1988375390 @default.
- W2058078905 cites W1989073099 @default.
- W2058078905 cites W1989338861 @default.
- W2058078905 cites W1992001407 @default.
- W2058078905 cites W1992264039 @default.
- W2058078905 cites W1993369825 @default.
- W2058078905 cites W1993980341 @default.
- W2058078905 cites W1995330222 @default.
- W2058078905 cites W1995705528 @default.
- W2058078905 cites W1996081689 @default.
- W2058078905 cites W1997124162 @default.
- W2058078905 cites W1997186013 @default.
- W2058078905 cites W1998698456 @default.
- W2058078905 cites W2003380041 @default.
- W2058078905 cites W2004767262 @default.
- W2058078905 cites W2006210468 @default.
- W2058078905 cites W2009967312 @default.
- W2058078905 cites W2010228711 @default.
- W2058078905 cites W2011350367 @default.
- W2058078905 cites W2011557706 @default.
- W2058078905 cites W2013290769 @default.
- W2058078905 cites W2014550477 @default.
- W2058078905 cites W2015697709 @default.
- W2058078905 cites W2017417965 @default.
- W2058078905 cites W2019705381 @default.
- W2058078905 cites W2020352730 @default.
- W2058078905 cites W2020387552 @default.
- W2058078905 cites W2020588358 @default.
- W2058078905 cites W2020877995 @default.
- W2058078905 cites W2022124390 @default.
- W2058078905 cites W2023966975 @default.
- W2058078905 cites W2023971821 @default.
- W2058078905 cites W2024903483 @default.
- W2058078905 cites W2025307866 @default.
- W2058078905 cites W2027777473 @default.
- W2058078905 cites W2030623240 @default.
- W2058078905 cites W2031212310 @default.
- W2058078905 cites W2031943544 @default.
- W2058078905 cites W2032339313 @default.
- W2058078905 cites W2033089640 @default.
- W2058078905 cites W2033980432 @default.