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• W2058080216 abstract "Since the advent of multiagent adjuvant chemotherapy, survival among patients with localized osteosarcoma has improved to 60% or more. Pulmonary relapse, the most common cause of treatment failure, is associated with less than 25% long-term survival; central nervous system (CNS) metastasis, when it occurs, often presents as a catastrophic clinical event in preterminal patients.The authors report a patient with osteosarcoma who had an isolated pulmonary relapse and a subsequent isolated CNS relapse. Complete surgical resection was accomplished on both occasions and followed in the initial instance by adjuvant chemotherapy and in the latter instance by adjuvant whole-brain irradiation.An isolated CNS metastasis was resected and adjuvant whole brain irradiation was administered; the patient is alive and relapse free more than 5 years later.Patients with osteosarcoma in whom isolated, resectable metastases develop can derive benefit from gross total resection followed by adjuvant chemotherapy or radiation therapy for microscopic residual disease." @default.
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• W2058080216 date "1993-08-15" @default.
• W2058080216 modified "2023-10-06" @default.
• W2058080216 title "Long-term survival after central nervous system relapse in a patient with osteosarcoma" @default.
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• W2058080216 doi "https://doi.org/10.1002/1097-0142(19930815)72:4<1203::aid-cncr2820720412>3.0.co;2-p" @default.
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