Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058080912> ?p ?o ?g. }
- W2058080912 endingPage "451" @default.
- W2058080912 startingPage "444" @default.
- W2058080912 abstract "Abstract Sepsis and septic shock remain an important medical problem, emphasizing the need to identify novel therapeutic opportunities. Hypovolemic hypotension, coagulation dysfunction, disturbed microcirculation, and multiorgan failure resulting from vascular leakage are often observed in these severe conditions. In the present study, we find that HKH20, a peptide derived from human high molecular weight kininogen (HK), down-regulates inflammatory reactions caused by Streptococcus pyogenes in a mouse model of sepsis. HK is a component of the pro-inflammatory and pro-coagulant contact system. Activation of the contact system in the bloodstream by S pyogenes leads to massive tissue damage in the lungs of the infected mice, which eventually results in the death of the animals. HKH20 inhibits activation of the contact system and protects mice with invasive S pyogenes infection from lung damage. In combination with clindamycin treatment, the peptide also significantly prolongs the survival of infected mice." @default.
- W2058080912 created "2016-06-24" @default.
- W2058080912 creator A5005892505 @default.
- W2058080912 creator A5020295523 @default.
- W2058080912 creator A5020345288 @default.
- W2058080912 creator A5045374933 @default.
- W2058080912 creator A5061549353 @default.
- W2058080912 creator A5064614661 @default.
- W2058080912 creator A5085263597 @default.
- W2058080912 creator A5090339554 @default.
- W2058080912 date "2009-07-09" @default.
- W2058080912 modified "2023-10-16" @default.
- W2058080912 title "Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen" @default.
- W2058080912 cites W111924924 @default.
- W2058080912 cites W143880323 @default.
- W2058080912 cites W1455002925 @default.
- W2058080912 cites W1483707658 @default.
- W2058080912 cites W1485002903 @default.
- W2058080912 cites W1541720947 @default.
- W2058080912 cites W1566240917 @default.
- W2058080912 cites W1570407438 @default.
- W2058080912 cites W1964494436 @default.
- W2058080912 cites W1967050835 @default.
- W2058080912 cites W1971473483 @default.
- W2058080912 cites W1975979946 @default.
- W2058080912 cites W1977777565 @default.
- W2058080912 cites W1980895202 @default.
- W2058080912 cites W1982696413 @default.
- W2058080912 cites W1984649993 @default.
- W2058080912 cites W1993140023 @default.
- W2058080912 cites W2006951698 @default.
- W2058080912 cites W2008082616 @default.
- W2058080912 cites W2020552766 @default.
- W2058080912 cites W2032158286 @default.
- W2058080912 cites W2044158085 @default.
- W2058080912 cites W2060290871 @default.
- W2058080912 cites W2062530800 @default.
- W2058080912 cites W2078012881 @default.
- W2058080912 cites W2079008038 @default.
- W2058080912 cites W2101108802 @default.
- W2058080912 cites W2115785705 @default.
- W2058080912 cites W2116948461 @default.
- W2058080912 cites W2121139943 @default.
- W2058080912 cites W2122434934 @default.
- W2058080912 cites W2125539176 @default.
- W2058080912 cites W2131062668 @default.
- W2058080912 cites W2147115561 @default.
- W2058080912 cites W2160217307 @default.
- W2058080912 cites W2160388336 @default.
- W2058080912 cites W2171780167 @default.
- W2058080912 cites W2279412500 @default.
- W2058080912 doi "https://doi.org/10.1182/blood-2008-10-182527" @default.
- W2058080912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19433860" @default.
- W2058080912 hasPublicationYear "2009" @default.
- W2058080912 type Work @default.
- W2058080912 sameAs 2058080912 @default.
- W2058080912 citedByCount "44" @default.
- W2058080912 countsByYear W20580809122012 @default.
- W2058080912 countsByYear W20580809122013 @default.
- W2058080912 countsByYear W20580809122014 @default.
- W2058080912 countsByYear W20580809122015 @default.
- W2058080912 countsByYear W20580809122016 @default.
- W2058080912 countsByYear W20580809122017 @default.
- W2058080912 countsByYear W20580809122018 @default.
- W2058080912 countsByYear W20580809122019 @default.
- W2058080912 countsByYear W20580809122020 @default.
- W2058080912 countsByYear W20580809122021 @default.
- W2058080912 countsByYear W20580809122022 @default.
- W2058080912 countsByYear W20580809122023 @default.
- W2058080912 crossrefType "journal-article" @default.
- W2058080912 hasAuthorship W2058080912A5005892505 @default.
- W2058080912 hasAuthorship W2058080912A5020295523 @default.
- W2058080912 hasAuthorship W2058080912A5020345288 @default.
- W2058080912 hasAuthorship W2058080912A5045374933 @default.
- W2058080912 hasAuthorship W2058080912A5061549353 @default.
- W2058080912 hasAuthorship W2058080912A5064614661 @default.
- W2058080912 hasAuthorship W2058080912A5085263597 @default.
- W2058080912 hasAuthorship W2058080912A5090339554 @default.
- W2058080912 hasBestOaLocation W20580809121 @default.
- W2058080912 hasConcept C126322002 @default.
- W2058080912 hasConcept C12722491 @default.
- W2058080912 hasConcept C170493617 @default.
- W2058080912 hasConcept C203014093 @default.
- W2058080912 hasConcept C2776914184 @default.
- W2058080912 hasConcept C2777628635 @default.
- W2058080912 hasConcept C2777714996 @default.
- W2058080912 hasConcept C2777902427 @default.
- W2058080912 hasConcept C2778384902 @default.
- W2058080912 hasConcept C2778734968 @default.
- W2058080912 hasConcept C2779306812 @default.
- W2058080912 hasConcept C2779489039 @default.
- W2058080912 hasConcept C2779591629 @default.
- W2058080912 hasConcept C2781300812 @default.
- W2058080912 hasConcept C2911084887 @default.
- W2058080912 hasConcept C523546767 @default.
- W2058080912 hasConcept C54355233 @default.
- W2058080912 hasConcept C71924100 @default.
- W2058080912 hasConcept C86803240 @default.