FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058080945> ?p ?o ?g. }

• W2058080945 endingPage "1820" @default.
• W2058080945 startingPage "1813" @default.
• W2058080945 abstract "We measured lead concentrations in three hemoglobin-based oxygen carriers (HBOCs; Oxyglobin®, Hemopure®, and Hemolink™) and compared them with lead concentrations from blood-bank blood. Oxyhemoglobin dissociation was measured with large concentrations of lead in bovine HBOC, with or without bovine blood, and in bovine blood. Samples of each were prepared by combining one with normal saline (control), the second with small lead concentrations (22 μg/dL), and the third with toxic lead concentrations (70 μg/dL). They were blended in 2 tonometers at oxygen concentrations (2.5%, 5%, 8%, 10%, 21%, and 95%) with 5% CO2 and the remainder nitrogen for 5 min per sample after a 15-min wash-in with each level of oxygen and were measured with co-oximetry. Oxygen saturation was plotted against PO2, fitting fourth-order polynomial nonlinear regression to the data. The lead concentrations of the three HBOCs were 0.51, 0.22, 0.40 μg/dL. There were no clinically important differences of the oxyhemoglobin dissociation curves as a function of lead concentration. The lead concentrations of the three tested HBOCs were small and no larger than the average for blood-bank blood. The presence of increasing concentrations of lead in either concentrated solution of bovine HBOC or a 1:1 mixture of bovine HBOC and native bovine blood does not appear to affect hemoglobin oxygenation in an acute in vitro model of increased lead concentrations. IMPLICATIONS: Gunshot wounds rapidly increase circulating lead concentrations. Lead concentrations are small in three hemoglobin-based oxygen carriers (HBOCs), and HBOCs and/or bovine blood do not appear to be affected by lead concentrations in terms of immediate oxygen on-loading and off-loading. HBOCs may be useful in patients with gunshot wounds." @default.
• W2058080945 created "2016-06-24" @default.
• W2058080945 creator A5014083380 @default.
• W2058080945 creator A5016011260 @default.
• W2058080945 creator A5022053786 @default.
• W2058080945 creator A5023746224 @default.
• W2058080945 creator A5030986983 @default.
• W2058080945 creator A5046730976 @default.
• W2058080945 creator A5049303025 @default.
• W2058080945 creator A5070345115 @default.
• W2058080945 creator A5073821607 @default.
• W2058080945 date "2003-06-01" @default.
• W2058080945 modified "2023-10-16" @default.
• W2058080945 title "Does Lead Interfere with Hemoglobin-Based Oxygen Carrier (HBOC) Function? A Pilot Study of Lead Concentrations in Three Approved or Tested HBOCs and Oxyhemoglobin Dissociation with HBOCs and/or Bovine Blood with Varying Lead Concentrations" @default.
• W2058080945 cites W1952336491 @default.
• W2058080945 cites W1967169588 @default.
• W2058080945 cites W1980258811 @default.
• W2058080945 cites W1990399491 @default.
• W2058080945 cites W2006282977 @default.
• W2058080945 cites W2008788211 @default.
• W2058080945 cites W2044764593 @default.
• W2058080945 cites W2050905302 @default.
• W2058080945 cites W2064875464 @default.
• W2058080945 cites W2072776316 @default.
• W2058080945 cites W2080318418 @default.
• W2058080945 cites W2087719451 @default.
• W2058080945 cites W2090424695 @default.
• W2058080945 cites W2115526102 @default.
• W2058080945 cites W2135405351 @default.
• W2058080945 cites W2136599482 @default.
• W2058080945 cites W2319400944 @default.
• W2058080945 cites W4243090307 @default.
• W2058080945 doi "https://doi.org/10.1213/01.ane.0000062517.13989.b5" @default.
• W2058080945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12761018" @default.
• W2058080945 hasPublicationYear "2003" @default.
• W2058080945 type Work @default.
• W2058080945 sameAs 2058080945 @default.
• W2058080945 citedByCount "5" @default.
• W2058080945 countsByYear W20580809452014 @default.
• W2058080945 countsByYear W20580809452022 @default.
• W2058080945 crossrefType "journal-article" @default.
• W2058080945 hasAuthorship W2058080945A5014083380 @default.
• W2058080945 hasAuthorship W2058080945A5016011260 @default.
• W2058080945 hasAuthorship W2058080945A5022053786 @default.
• W2058080945 hasAuthorship W2058080945A5023746224 @default.
• W2058080945 hasAuthorship W2058080945A5030986983 @default.
• W2058080945 hasAuthorship W2058080945A5046730976 @default.
• W2058080945 hasAuthorship W2058080945A5049303025 @default.
• W2058080945 hasAuthorship W2058080945A5070345115 @default.
• W2058080945 hasAuthorship W2058080945A5073821607 @default.
• W2058080945 hasBestOaLocation W20580809451 @default.
• W2058080945 hasConcept C126322002 @default.
• W2058080945 hasConcept C127503593 @default.
• W2058080945 hasConcept C178790620 @default.
• W2058080945 hasConcept C185592680 @default.
• W2058080945 hasConcept C2778917026 @default.
• W2058080945 hasConcept C42219234 @default.
• W2058080945 hasConcept C43617362 @default.
• W2058080945 hasConcept C540031477 @default.
• W2058080945 hasConcept C71924100 @default.
• W2058080945 hasConceptScore W2058080945C126322002 @default.
• W2058080945 hasConceptScore W2058080945C127503593 @default.
• W2058080945 hasConceptScore W2058080945C178790620 @default.
• W2058080945 hasConceptScore W2058080945C185592680 @default.
• W2058080945 hasConceptScore W2058080945C2778917026 @default.
• W2058080945 hasConceptScore W2058080945C42219234 @default.
• W2058080945 hasConceptScore W2058080945C43617362 @default.
• W2058080945 hasConceptScore W2058080945C540031477 @default.
• W2058080945 hasConceptScore W2058080945C71924100 @default.
• W2058080945 hasLocation W20580809451 @default.
• W2058080945 hasLocation W20580809452 @default.
• W2058080945 hasOpenAccess W2058080945 @default.
• W2058080945 hasPrimaryLocation W20580809451 @default.
• W2058080945 hasRelatedWork W128353271 @default.
• W2058080945 hasRelatedWork W1492302801 @default.
• W2058080945 hasRelatedWork W1806324926 @default.
• W2058080945 hasRelatedWork W2020111157 @default.
• W2058080945 hasRelatedWork W2043329082 @default.
• W2058080945 hasRelatedWork W2078515178 @default.
• W2058080945 hasRelatedWork W2312770288 @default.
• W2058080945 hasRelatedWork W2909563711 @default.
• W2058080945 hasRelatedWork W2963296325 @default.
• W2058080945 hasRelatedWork W342023778 @default.
• W2058080945 isParatext "false" @default.
• W2058080945 isRetracted "false" @default.
• W2058080945 magId "2058080945" @default.
• W2058080945 workType "article" @default.