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- W2058082161 abstract "Limitation of conventional human Ether-a-go-go Related Gene (hERG) assay and QT prolongation testing for accurate prediction of Torsades de Pointes (TdP) by compounds showed us the necessity of a new approach to evaluate global cardiac safety. As one of the advanced applications of an on-chip cellomics system, on-chip cardiomyocyte cell network-based re-entry model assay has the potential to measure the TdP probability as a pre-clinical test for cardiac safety. This system also can estimate the heart pressure, Na, K, and Ca ion channel conditions using a single cell-based optical/electrical measurement system. In this presentation, we present the system setup and then its possible application for drug discovery and toxicology." @default.
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- W2058082161 date "2010-04-01" @default.
- W2058082161 modified "2023-09-27" @default.
- W2058082161 title "On-chip Cellomics Technology for Drug Screening System Using Cardiomyocyte Cells from Human Stem Cell" @default.
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- W2058082161 doi "https://doi.org/10.1248/yakushi.130.545" @default.
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