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• W2058082743 abstract "A multilayer hemin/G-quadruplex DNAzyme wrapped gold nanoparticle (M-DNAzyme/AuNP) tag was designed for ultrasensitive chemiluminescence (CL) imaging. By combining with a disposable protein array, an ultrasensitive and high-throughput multiplex CL immunoassay method was proposed for simultaneous detection of four cancer biomarkers. The M-DNAzyme/AuNP tag was prepared by assembling high ratio of alkylthiol-capped signal DNA containing multiple G-quadruplex sequences to biotinylated DNA on AuNPs and then reacting with hemin to form multilayer hemin/G-quadruplex DNAzyme units. It could be bound to the biotinylated secondary antibody of sandwich immunocomplex by biotin–streptavidin conjugation to catalyze a CL reaction on a protein array, which produced strong CL emission. Under optimal conditions, the CL signals could be simultaneously collected by a charge-coupled device for ultrasensitive multiplex CL imaging of cancer biomarkers. Using α-fetoprotein, human chorionic gonadotrophin-β, carcinoma antigen 125, and carcinoembryonic antigen as model analytes, the proposed immunoassay method showed high sensitivities and wide linear ranges in a simple, cheap and high throughput way. The M-DNAzyme/AuNP as a universal signal tag as well as the protein chip could be suitable for mass production for economical, portable and multianalyte assay, showing a promising potential in application to clinic and other relative fields." @default.
• W2058082743 created "2016-06-24" @default.
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• W2058082743 date "2013-05-01" @default.
• W2058082743 modified "2023-10-16" @default.
• W2058082743 title "Multilayer hemin/G-quadruplex wrapped gold nanoparticles as tag for ultrasensitive multiplex immunoassay by chemiluminescence imaging" @default.
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• W2058082743 doi "https://doi.org/10.1016/j.bios.2012.12.051" @default.
• W2058082743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23356995" @default.
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