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• W2058092457 startingPage "131" @default.
• W2058092457 abstract "Graft rejection in transplant patients is managed clinically by suppressing T-cell function with immunosuppressive drugs such as prednisolone and methylprednisolone. In such immunocompromised hosts, human cytomegalovirus (HCMV) is an important opportunistic pathogen and can cause severe morbidity and mortality. Currently, the effect of glucocorticosteroids (GCSs) on the HCMV life cycle remains unclear. Previous reports showed enhanced lytic replication of HCMV in vitro in the presence of GCSs. In the present study, we explored the implications of steroid exposure on latency and reactivation. We observed a direct effect of several GCSs used in the clinic on the activation of a quiescent viral major immediate-early promoter in stably transfected THP-1 monocytic cells. This activation was prevented by the glucocorticoid receptor (GR) antagonist Ru486 and by shRNA-mediated knockdown of the GR. Consistent with this observation, prednisolone treatment of latently infected primary monocytes resulted in HCMV reactivation. Analysis of the phenotype of these cells showed that treatment with GCSs was correlated with differentiation to an anti-inflammatory macrophage-like cell type. On the basis that these observations may be pertinent to HCMV reactivation in post-transplant settings, we retrospectively evaluated the incidence, viral kinetics and viral load of HCMV in liver transplant patients in the presence or absence of GCS treatment. We observed that combination therapy of baseline prednisolone and augmented methylprednisolone, upon organ rejection, significantly increased the incidence of HCMV infection in the intermediate risk group where donor and recipient are both HCMV seropositive (D+R+) to levels comparable with the high risk D+R- group." @default.
• W2058092457 created "2016-06-24" @default.
• W2058092457 creator A5003851172 @default.
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• W2058092457 creator A5065248443 @default.
• W2058092457 creator A5069894218 @default.
• W2058092457 creator A5073613780 @default.
• W2058092457 date "2015-01-01" @default.
• W2058092457 modified "2023-10-14" @default.
• W2058092457 title "Glucocorticosteroids trigger reactivation of human cytomegalovirus from latently infected myeloid cells and increase the risk for HCMV infection in D+R+ liver transplant patients" @default.
• W2058092457 cites W1501688137 @default.
• W2058092457 cites W1536477464 @default.
• W2058092457 cites W1568041502 @default.
• W2058092457 cites W1572335427 @default.
• W2058092457 cites W1590429672 @default.
• W2058092457 cites W1594205240 @default.
• W2058092457 cites W1597606892 @default.
• W2058092457 cites W1763057720 @default.
• W2058092457 cites W1763782658 @default.
• W2058092457 cites W1773837359 @default.
• W2058092457 cites W1809580973 @default.
• W2058092457 cites W1835200336 @default.
• W2058092457 cites W1885968493 @default.
• W2058092457 cites W1904456060 @default.
• W2058092457 cites W1932638060 @default.
• W2058092457 cites W1933815796 @default.
• W2058092457 cites W1966858455 @default.
• W2058092457 cites W1982286823 @default.
• W2058092457 cites W1991001144 @default.
• W2058092457 cites W2001599204 @default.
• W2058092457 cites W2003979549 @default.
• W2058092457 cites W2014088145 @default.
• W2058092457 cites W2016750728 @default.
• W2058092457 cites W2016895604 @default.
• W2058092457 cites W2019369000 @default.
• W2058092457 cites W2022894063 @default.
• W2058092457 cites W2026239217 @default.
• W2058092457 cites W2030097812 @default.
• W2058092457 cites W2036700876 @default.
• W2058092457 cites W2037306080 @default.
• W2058092457 cites W2037809846 @default.
• W2058092457 cites W2045264829 @default.
• W2058092457 cites W2053901884 @default.
• W2058092457 cites W2055796578 @default.
• W2058092457 cites W2058446381 @default.
• W2058092457 cites W2060107805 @default.
• W2058092457 cites W2064796142 @default.
• W2058092457 cites W2065104803 @default.
• W2058092457 cites W2066455030 @default.
• W2058092457 cites W2067895450 @default.
• W2058092457 cites W2070883852 @default.
• W2058092457 cites W2073493139 @default.
• W2058092457 cites W2073701099 @default.
• W2058092457 cites W2074843439 @default.
• W2058092457 cites W2076361525 @default.
• W2058092457 cites W2076613886 @default.
• W2058092457 cites W2080841416 @default.
• W2058092457 cites W2081280611 @default.
• W2058092457 cites W2081286868 @default.
• W2058092457 cites W2084704032 @default.
• W2058092457 cites W2091478221 @default.
• W2058092457 cites W2091756255 @default.
• W2058092457 cites W2092733738 @default.
• W2058092457 cites W2099784004 @default.
• W2058092457 cites W2105019625 @default.
• W2058092457 cites W2105928329 @default.
• W2058092457 cites W2106230667 @default.
• W2058092457 cites W2113603236 @default.
• W2058092457 cites W2117934021 @default.
• W2058092457 cites W2118937969 @default.
• W2058092457 cites W2119194984 @default.
• W2058092457 cites W2119930315 @default.
• W2058092457 cites W2121658131 @default.
• W2058092457 cites W2123183493 @default.
• W2058092457 cites W2127497318 @default.
• W2058092457 cites W2128092549 @default.
• W2058092457 cites W2129248366 @default.
• W2058092457 cites W2134764060 @default.
• W2058092457 cites W2135065794 @default.
• W2058092457 cites W2136013587 @default.
• W2058092457 cites W2138126190 @default.
• W2058092457 cites W2138720696 @default.
• W2058092457 cites W2138891136 @default.
• W2058092457 cites W2140413558 @default.
• W2058092457 cites W2146193551 @default.
• W2058092457 cites W2146231867 @default.
• W2058092457 cites W2146339219 @default.
• W2058092457 cites W2147428033 @default.
• W2058092457 cites W2166478118 @default.
• W2058092457 cites W2167223040 @default.
• W2058092457 cites W2168421200 @default.
• W2058092457 cites W2168744744 @default.
• W2058092457 cites W2170487369 @default.
• W2058092457 cites W2170738140 @default.

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