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• W2058093172 abstract "BODIPY-erythromycin probes of bacterial ribosomes were designed and synthesized by attaching a BODIPY fluorophore to the 4''- and 9-positions of the erythromycin structure. The probes exhibited excellent binding affinity to bacterial ribosomes and competed with erythromycin and other drugs whose binding sites are in the same vicinity of the 50S subunit. The synthetic fluorescent probe 5 was successfully adapted in our ultra high-throughput screening (uHTS) to identify novel ribosome inhibitors." @default.
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• W2058093172 date "2006-02-01" @default.
• W2058093172 modified "2023-10-08" @default.
• W2058093172 title "Design, synthesis, and biological evaluation of BODIPY®–erythromycin probes for bacterial ribosomes" @default.
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• W2058093172 doi "https://doi.org/10.1016/j.bmcl.2005.11.028" @default.
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