FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058096544> ?p ?o ?g. }

• W2058096544 endingPage "995" @default.
• W2058096544 startingPage "986" @default.
• W2058096544 abstract "The three PRL (phosphatases of regenerating liver) protein tyrosine phosphatases (PRL-1, -2 and -3) have been identified as key contributors to metastasis in several human cancers, yet the molecular basis of their pro-oncogenic property is unclear. Among the subfamily of PRL phosphatases, overexpression of PRL-2 in breast cancer cells has been shown to promote tumor growth by a mechanism that remains to be uncovered. Here we show that PRL-2 regulates intracellular magnesium levels by forming a functional heterodimer with the magnesium transporter CNNM3. We further reveal that CNNM3 is not a phosphorylated substrate of PRL-2, and that the interaction occurs through a loop unique to the CBS pair domains of CNNM3 that exists only in organisms having PRL orthologs. Supporting the role of PRL-2 in cellular magnesium transport is the observation that PRL-2 knockdown results in a substantial decrease of cellular magnesium influx. Furthermore, in PRL-2 knockout mice, serum magnesium levels were significantly elevated as compared with control animals, indicating a pivotal role for PRL-2 in regulating cellular magnesium homeostasis. Although the expression levels of CNNM3 remained unchanged after magnesium depletion of various cancer cell lines, the interaction between endogenous PRL-2 and CNNM3 was markedly increased. Importantly, xenograft tumor assays with CNNM3 and a mutant form that does not associate with PRL-2 confirm that CNNM3 is itself pro-oncogenic, and that the PRL-2/CNNM3 association is important for conferring transforming activities. This finding is further confirmed from data in human breast cancer tissues showing that CNNM3 levels correlate positively with both PRL-2 expression and the tumor proliferative index. In summary, we demonstrate that oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter." @default.
• W2058096544 created "2016-06-24" @default.
• W2058096544 creator A5007653418 @default.
• W2058096544 creator A5017989928 @default.
• W2058096544 creator A5027114537 @default.
• W2058096544 creator A5058001372 @default.
• W2058096544 creator A5061110332 @default.
• W2058096544 creator A5064674610 @default.
• W2058096544 creator A5070217428 @default.
• W2058096544 creator A5070976084 @default.
• W2058096544 creator A5073985215 @default.
• W2058096544 date "2014-03-17" @default.
• W2058096544 modified "2023-10-01" @default.
• W2058096544 title "The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis" @default.
• W2058096544 cites W1487122816 @default.
• W2058096544 cites W1635926281 @default.
• W2058096544 cites W1969918683 @default.
• W2058096544 cites W1974870493 @default.
• W2058096544 cites W1975746476 @default.
• W2058096544 cites W1976111921 @default.
• W2058096544 cites W1983064104 @default.
• W2058096544 cites W1985948706 @default.
• W2058096544 cites W1992543140 @default.
• W2058096544 cites W2011398963 @default.
• W2058096544 cites W2020585295 @default.
• W2058096544 cites W2027064373 @default.
• W2058096544 cites W2035637319 @default.
• W2058096544 cites W2043986623 @default.
• W2058096544 cites W2055933325 @default.
• W2058096544 cites W2059286008 @default.
• W2058096544 cites W2061770256 @default.
• W2058096544 cites W2062088852 @default.
• W2058096544 cites W2077321668 @default.
• W2058096544 cites W2079820221 @default.
• W2058096544 cites W2084227839 @default.
• W2058096544 cites W2087355395 @default.
• W2058096544 cites W2090777221 @default.
• W2058096544 cites W2097445405 @default.
• W2058096544 cites W2100258190 @default.
• W2058096544 cites W2100900404 @default.
• W2058096544 cites W2103565184 @default.
• W2058096544 cites W2107787330 @default.
• W2058096544 cites W2109897538 @default.
• W2058096544 cites W2127660300 @default.
• W2058096544 cites W2130860611 @default.
• W2058096544 cites W2132487225 @default.
• W2058096544 cites W2139228286 @default.
• W2058096544 cites W2141260882 @default.
• W2058096544 cites W2144265114 @default.
• W2058096544 cites W2150426114 @default.
• W2058096544 cites W2152356401 @default.
• W2058096544 cites W2155217644 @default.
• W2058096544 cites W2163154369 @default.
• W2058096544 cites W2168062869 @default.
• W2058096544 cites W2169344612 @default.
• W2058096544 cites W2170456753 @default.
• W2058096544 cites W2172008304 @default.
• W2058096544 doi "https://doi.org/10.1038/onc.2014.33" @default.
• W2058096544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24632616" @default.
• W2058096544 hasPublicationYear "2014" @default.
• W2058096544 type Work @default.
• W2058096544 sameAs 2058096544 @default.
• W2058096544 citedByCount "91" @default.
• W2058096544 countsByYear W20580965442015 @default.
• W2058096544 countsByYear W20580965442016 @default.
• W2058096544 countsByYear W20580965442017 @default.
• W2058096544 countsByYear W20580965442018 @default.
• W2058096544 countsByYear W20580965442019 @default.
• W2058096544 countsByYear W20580965442020 @default.
• W2058096544 countsByYear W20580965442021 @default.
• W2058096544 countsByYear W20580965442022 @default.
• W2058096544 countsByYear W20580965442023 @default.
• W2058096544 crossrefType "journal-article" @default.
• W2058096544 hasAuthorship W2058096544A5007653418 @default.
• W2058096544 hasAuthorship W2058096544A5017989928 @default.
• W2058096544 hasAuthorship W2058096544A5027114537 @default.
• W2058096544 hasAuthorship W2058096544A5058001372 @default.
• W2058096544 hasAuthorship W2058096544A5061110332 @default.
• W2058096544 hasAuthorship W2058096544A5064674610 @default.
• W2058096544 hasAuthorship W2058096544A5070217428 @default.
• W2058096544 hasAuthorship W2058096544A5070976084 @default.
• W2058096544 hasAuthorship W2058096544A5073985215 @default.
• W2058096544 hasBestOaLocation W20580965441 @default.
• W2058096544 hasConcept C104317684 @default.
• W2058096544 hasConcept C11960822 @default.
• W2058096544 hasConcept C126322002 @default.
• W2058096544 hasConcept C134018914 @default.
• W2058096544 hasConcept C173396325 @default.
• W2058096544 hasConcept C178666793 @default.
• W2058096544 hasConcept C2776165026 @default.
• W2058096544 hasConcept C2777553839 @default.
• W2058096544 hasConcept C55493867 @default.
• W2058096544 hasConcept C555283112 @default.
• W2058096544 hasConcept C71924100 @default.
• W2058096544 hasConcept C85528070 @default.
• W2058096544 hasConcept C86803240 @default.
• W2058096544 hasConcept C95444343 @default.
• W2058096544 hasConceptScore W2058096544C104317684 @default.

• next