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- W2058097046 abstract "The output of triglyceride by the perfused rat liver was depressed by heparin (Upjohn) added to the medium in vitro. The impairment in output of triglyceride by the liver which resulted from fasting, alloxan diabetes, and from poisoning of the animal with carbon tetrachloride was observed whether or not heparin was used as an anticoagulant. The output of triglyceride by the liver was inhibited significantly by crystalline heparin (Sigma) only at the smallest concentration (0.42 USP units/ml perfusate) of heparin added to the medium. The release of lipolytic activity by the liver was stimulated as the concentration of heparin in the medium was increased; the maximal effect was obtained at a concentration of 42 units heparin/ml perfusate. Paradoxically, as the lipolytic activity in the medium increased, the inhibition of output of triglyceride by heparin diminished. The uptake and utilization by the liver of chylomicra labeled with palmitic acid-1-14C was accelerated by crystalline heparin, presumably as a result of the increased lipolytic activity. There was, however, a real, albeit smaller, utilization of chylomicron triglyceride when heparin was omitted from the medium. One can surmise from these observations that the output of triglyceride into the very low density lipoprotein (VLDL) by the liver and the uptake of either chylomicron triglyceride or the VLDL-triglyceride occur by different cellular mechanisms, since heparin appears to affect each of these processes in diverse manners." @default.
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- W2058097046 title "The effect of heparin on the metabolism of triglycerides by the liver" @default.
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- W2058097046 doi "https://doi.org/10.1016/0006-2952(70)90196-6" @default.
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