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- W2058105655 abstract "Abstract The toxicokinetics of nickel was studied in normal and glutathione depleted rats. The depletion of glutathione resulted in an increased retention of 63nickel in plasma and in body organs with concomitant decrease in 63nickel elimination in urine. In both the groups, kidney was the major site of accumulation of 63nickel followed by lung, heart, spleen and liver. The injected nickel was mainly eliminated via urine. The time course elimination of 63nickel followed first order kinetics and the correlation between the time and plasma/or tissue nickel concentration was statistically significant. Our results suggest that depletion of glutathione may increase the toxicity of nickel by altering its toxicokinetics." @default.
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- W2058105655 title "Toxicokinetics of nickel in glutathione depleted rats" @default.
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- W2058105655 doi "https://doi.org/10.1016/0045-6535(90)90115-a" @default.
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