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• W2058121337 abstract "• We identify disease-specific cognitive-behavioral profiles in parkinsonism. • A reduced semantic fluency is linked to tauopathies. • Impaired verbal learning may be present in LBD patients. • Semantic fluency discriminates between LBD and tauopathies with high accuracy. We investigated disease-specific cognitive profiles and their neural correlates in Lewy-body diseases (LBD) and tauopathies by CERAD assessment and FDG-PET. Analyses revealed a significant interaction between reduced semantic fluency in tauopathies and impaired verbal learning in LBD. Semantic fluency discriminated between groups with high accuracy (83% ) . Compared to LBD, tauopathy patients showed bilateral hypometabolism of midbrain, thalamus, middle cingulate gyrus and supplementary motor/premotor cortex. In the reverse contrast, LBD patients exhibited bilateral hypometabolism in posterior parietal cortex, precuneus and inferior temporal gyrus extending into occipital and frontal cortices. In diagnosis-independent voxel-based analyses, verbal learning/memory correlated with left temporal and right parietal metabolism, while fluency was coupled to bilateral striatal and frontal metabolism. Naming correlated with left frontal metabolism and drawing with metabolism in bilateral temporal and left frontal regions. In line with disease-specific patterns of regional glucose metabolism, tauopathies and LBD show distinct cognitive profiles, which may assist clinical differentiation." @default.
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• W2058121337 date "2013-11-01" @default.
• W2058121337 modified "2023-10-17" @default.
• W2058121337 title "Neural correlates of cognitive dysfunction in Lewy body diseases and tauopathies: Combined assessment with FDG-PET and the CERAD test battery" @default.
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• W2058121337 doi "https://doi.org/10.1016/j.bandl.2013.10.004" @default.
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