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- W2058124782 abstract "It has been previously shown that Escherichia coli endotoxin (ENDO) reduces the pressor effect of phenylephrine. This work attempted to define precisely the involvement of vascular alpha-adrenoceptors in this action. The dose-response curves of three alpha-agonists noradrenaline, St 587 and B-HT 933 in pithed rats were shifted rightwards by pretreatment (i.v. injection of 10 and 100 micrograms/kg) with ENDO. ENDO 10 and 30 micrograms shifted the dose-response curve of noradrenaline in perfused rat kidney. It can be suggested that ENDO has a potent blocking action on vascular alpha-adrenoceptors without evident discrimination between alpha 1 and alpha 2 subtypes." @default.
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- W2058124782 date "1986-08-01" @default.
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- W2058124782 title "Vascular α-adrenoceptor blockade by E. coli endotoxin in the rat" @default.
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- W2058124782 doi "https://doi.org/10.1016/0014-2999(86)90212-8" @default.
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