FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058125622> ?p ?o ?g. }

• W2058125622 abstract "Numerous studies have highlighted the role of the proton donor characteristics of the phenol group of 17β-estradiol (E(2)) in its association with the estrogen receptor alpha (ERα). Since the substitutions at position C((11)) have been reported to modulate this association, we hypothesized that such substitutions may modify the phenol acidity. Hence, phenol gas-phase acidity of nine C((11))-substituted E(2)-derivatives were evaluated using the extended Cooks' kinetic method, which is a method widely used to determine thermochemical properties by mass spectrometry. To enhance accuracy in data collection we recorded data from several instruments, including quadrupole ion trap, triple quadrupole, and hybrid QqTOF. Indeed, we report for the first time the use of the QqTOF instrument to provide a novel means to improve data accuracy by giving access to an intermediate effective temperature range. All experimental gas-phase acidity values were supported by theoretical calculations. Our results confirmed the ability of distant substituents at C((11)) to modulate the phenol acidity through electrostatic interactions, electron withdrawing inductive effects, and mesomeric effects. However, no relationship was found between the phenol gas-phase acidity of investigated steroids and their binding affinity for ERα assessed in solution. Thus, our results highlight that the intrinsic properties of the hormone do not influence sufficiently the stabilization of the hormone/ERα complex. It is more likely that such stabilization would be more related to factors depending on the environment within the binding pocket such as hydrophobic, steric as well as direct intermolecular electrostatic effects between ERα residues and the substituted steroidal estrogens." @default.
• W2058125622 created "2016-06-24" @default.
• W2058125622 creator A5007639017 @default.
• W2058125622 creator A5035375779 @default.
• W2058125622 creator A5044386800 @default.
• W2058125622 creator A5064545408 @default.
• W2058125622 creator A5068430605 @default.
• W2058125622 creator A5069812226 @default.
• W2058125622 creator A5082934839 @default.
• W2058125622 creator A5089340124 @default.
• W2058125622 date "2012-10-02" @default.
• W2058125622 modified "2023-10-12" @default.
• W2058125622 title "Electronic Effects of 11β Substituted 17β-Estradiol Derivatives and Instrumental Effects on the Relative Gas Phase Acidity" @default.
• W2058125622 cites W1967040140 @default.
• W2058125622 cites W1968425544 @default.
• W2058125622 cites W1969712968 @default.
• W2058125622 cites W1978154339 @default.
• W2058125622 cites W1979424860 @default.
• W2058125622 cites W1986500833 @default.
• W2058125622 cites W1988545935 @default.
• W2058125622 cites W1991812652 @default.
• W2058125622 cites W1991829241 @default.
• W2058125622 cites W1996192821 @default.
• W2058125622 cites W1996435768 @default.
• W2058125622 cites W1998079120 @default.
• W2058125622 cites W2003719997 @default.
• W2058125622 cites W2013556958 @default.
• W2058125622 cites W2016905499 @default.
• W2058125622 cites W2022075378 @default.
• W2058125622 cites W2030687437 @default.
• W2058125622 cites W2032684012 @default.
• W2058125622 cites W2034639888 @default.
• W2058125622 cites W2042375109 @default.
• W2058125622 cites W2046339643 @default.
• W2058125622 cites W2046552498 @default.
• W2058125622 cites W2053837941 @default.
• W2058125622 cites W2054414019 @default.
• W2058125622 cites W2057710941 @default.
• W2058125622 cites W2060374353 @default.
• W2058125622 cites W2066204867 @default.
• W2058125622 cites W2066388864 @default.
• W2058125622 cites W2071023389 @default.
• W2058125622 cites W2075980282 @default.
• W2058125622 cites W2086957099 @default.
• W2058125622 cites W2092773862 @default.
• W2058125622 cites W2103107953 @default.
• W2058125622 cites W2104372768 @default.
• W2058125622 cites W2107161977 @default.
• W2058125622 cites W2107818576 @default.
• W2058125622 cites W2109105520 @default.
• W2058125622 cites W2122180791 @default.
• W2058125622 cites W2123034821 @default.
• W2058125622 cites W2130355932 @default.
• W2058125622 cites W2152142256 @default.
• W2058125622 cites W2324777999 @default.
• W2058125622 cites W2949507393 @default.
• W2058125622 cites W2950949150 @default.
• W2058125622 cites W3036723969 @default.
• W2058125622 doi "https://doi.org/10.1007/s13361-012-0486-8" @default.
• W2058125622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23055074" @default.
• W2058125622 hasPublicationYear "2012" @default.
• W2058125622 type Work @default.
• W2058125622 sameAs 2058125622 @default.
• W2058125622 citedByCount "2" @default.
• W2058125622 countsByYear W20581256222013 @default.
• W2058125622 countsByYear W20581256222017 @default.
• W2058125622 crossrefType "journal-article" @default.
• W2058125622 hasAuthorship W2058125622A5007639017 @default.
• W2058125622 hasAuthorship W2058125622A5035375779 @default.
• W2058125622 hasAuthorship W2058125622A5044386800 @default.
• W2058125622 hasAuthorship W2058125622A5064545408 @default.
• W2058125622 hasAuthorship W2058125622A5068430605 @default.
• W2058125622 hasAuthorship W2058125622A5069812226 @default.
• W2058125622 hasAuthorship W2058125622A5082934839 @default.
• W2058125622 hasAuthorship W2058125622A5089340124 @default.
• W2058125622 hasConcept C145148216 @default.
• W2058125622 hasConcept C162356407 @default.
• W2058125622 hasConcept C166950319 @default.
• W2058125622 hasConcept C178790620 @default.
• W2058125622 hasConcept C185592680 @default.
• W2058125622 hasConcept C201194858 @default.
• W2058125622 hasConcept C2777702071 @default.
• W2058125622 hasConcept C30095370 @default.
• W2058125622 hasConcept C32909587 @default.
• W2058125622 hasConcept C41339378 @default.
• W2058125622 hasConcept C43617362 @default.
• W2058125622 hasConcept C44280652 @default.
• W2058125622 hasConcept C53323650 @default.
• W2058125622 hasConcept C71240020 @default.
• W2058125622 hasConceptScore W2058125622C145148216 @default.
• W2058125622 hasConceptScore W2058125622C162356407 @default.
• W2058125622 hasConceptScore W2058125622C166950319 @default.
• W2058125622 hasConceptScore W2058125622C178790620 @default.
• W2058125622 hasConceptScore W2058125622C185592680 @default.
• W2058125622 hasConceptScore W2058125622C201194858 @default.
• W2058125622 hasConceptScore W2058125622C2777702071 @default.
• W2058125622 hasConceptScore W2058125622C30095370 @default.
• W2058125622 hasConceptScore W2058125622C32909587 @default.
• W2058125622 hasConceptScore W2058125622C41339378 @default.
• W2058125622 hasConceptScore W2058125622C43617362 @default.

• next